Pregabalin

Generic Name
Pregabalin
Brand Names
Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
Drug Type
Small Molecule
Chemical Formula
C8H17NO2
CAS Number
148553-50-8
Unique Ingredient Identifier
55JG375S6M
Background

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by bind...

Indication

Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions
Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
Associated Therapies
-
Clinical Trials
Related News

Neuropathic Pain Assessment Comparing Pregabalin and Paroxetine in Management of MS-induced Neuropathic Pain

First Posted Date
2006-02-13
Last Posted Date
2012-07-27
Lead Sponsor
University of Manitoba
Target Recruit Count
75
Registration Number
NCT00291148
Locations
🇨🇦

Multiple Sclerosis Clinic, Health Sciences Centre, Winnipeg, Manitoba, Canada

Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER).

Phase 4
Completed
Conditions
Epilepsy
First Posted Date
2006-02-08
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
98
Registration Number
NCT00288639
Locations
🇬🇷

Pfizer Investigational Site, Thessaloniki, Greece

A Safety Study Of Pregabalin In Fibromyalgia

Phase 3
Completed
Conditions
Fibromyalgia
First Posted Date
2006-01-27
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
500
Registration Number
NCT00282997
Locations
🇺🇸

Pfizer Investigational Site, Milwaukee, Wisconsin, United States

Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy

Phase 3
Completed
Conditions
Epilepsy, Partial
Interventions
Drug: Pregabalin
Drug: Lamotrigine
First Posted Date
2006-01-20
Last Posted Date
2021-01-28
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
660
Registration Number
NCT00280059
Locations
🇬🇧

Pfizer Investigational Site, Treliske, Truro, Cornwall, United Kingdom

Open Label Safety And Efficacy Study Of Pregabalin In Subjects With Nerve Pain Asociated With Human Immunodeficiency Virus (HIV) Neuropathy

Phase 3
Completed
Conditions
HIV Infections
Peripheral Neuropathy
Interventions
Drug: pregabalin
First Posted Date
2005-12-13
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
220
Registration Number
NCT00264875
Locations
🇵🇷

Pfizer Investigational Site, San Juan, Puerto Rico

Trial of Pregabalin, Alprazolam, and Placebo in Subjects With Anxiety Prior to Dental Procedure

Phase 2
Completed
Conditions
Dental Anxiety
First Posted Date
2005-10-28
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
90
Registration Number
NCT00245609
Locations
🇬🇧

Pfizer Investigational Site, Sheffield, United Kingdom

Effect of Paracetamol, Pregabalin and Dexamethasone on Pain and Opioid Requirements in Patients After Hip Operations

Phase 4
Completed
Conditions
Pain
Postoperative
First Posted Date
2005-10-10
Last Posted Date
2007-08-17
Lead Sponsor
Glostrup University Hospital, Copenhagen
Target Recruit Count
120
Registration Number
NCT00235261
Locations
🇩🇰

Department of anaesthesiology; Hoersholm Sygehus, Hoersholm, Frederiksborg Amt, Denmark

Study of Pregabalin Versus Placebo in the Treatment of Nerve Pain Associated With HIV Neuropathy

First Posted Date
2005-10-04
Last Posted Date
2021-02-09
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
302
Registration Number
NCT00232141
Locations
🇵🇷

Pfizer Investigational Site, San Juan, Puerto Rico

A Controlled Pregabalin Trial In Fibromyalgia

Phase 3
Completed
Conditions
Fibromyalgia
First Posted Date
2005-10-03
Last Posted Date
2021-01-26
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
740
Registration Number
NCT00230776
Locations
🇺🇸

Pfizer Investigational Site, Milwaukee, Wisconsin, United States

Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy

Phase 3
Completed
Conditions
Radiculopathy
First Posted Date
2005-09-12
Last Posted Date
2021-01-25
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
276
Registration Number
NCT00159705
Locations
🇹🇷

Pfizer Investigational Site, Istanbul, Turkey

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