Pregabalin

Generic Name
Pregabalin
Brand Names
Lyrica, Pregabalin Accord, Pregabalin Pfizer, Pregabalin Sandoz, Pregabalin Mylan, Pregabalin Zentiva
Drug Type
Small Molecule
Chemical Formula
C8H17NO2
CAS Number
148553-50-8
Unique Ingredient Identifier
55JG375S6M
Background

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by bind...

Indication

Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.

Associated Conditions
Diabetic Peripheral Neuropathic Pain (DPN), Epilepsies, Fibromyalgia, Generalized Anxiety Disorder, Neuropathic Pain, Partial-Onset Seizures, Peripheral Neuropathic Pain, Peripheral neuropathy, Postherpetic Neuralgia
Associated Therapies
-
Clinical Trials
Related News

Efficacy and Safety of Pregabalin vs Placebo for Generalized Anxiety Disorder (GAD) Symptoms in Subjects Discontinuing Benzodiazepine Treatment and Remaining 6 Weeks on Study Medication, Free From Benzodiazepine Use.

Phase 3
Completed
Conditions
Generalized Anxiety Disorder
Interventions
Drug: Placebo
Drug: Pregabalin
First Posted Date
2006-08-25
Last Posted Date
2021-02-09
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
108
Registration Number
NCT00368745
Locations
🇪🇸

Pfizer Investigational Site, Zamora, Spain

Analgetic and Anxiolytic Effect of Preoperative Pregabalin

First Posted Date
2006-07-19
Last Posted Date
2011-07-20
Lead Sponsor
Asker & Baerum Hospital
Target Recruit Count
50
Registration Number
NCT00353704
Locations
🇳🇴

Asker and Baerum Hospital, Rud, Norway

Study to Find Out if Therapy With the Drug Pregabalin Relieves Pain During Shingles Compared With Placebo

Phase 2
Terminated
Conditions
Herpes Zoster
Postherpetic Neuralgia
First Posted Date
2006-07-14
Last Posted Date
2011-04-14
Lead Sponsor
University of California, San Francisco
Target Recruit Count
34
Registration Number
NCT00352651
Locations
🇺🇸

UCSF Pain Clinical Research Center, San Francisco, California, United States

This Study is An Open-Label Trial Of Pregabalin In Patients With Fibromyalgia

Phase 3
Completed
Conditions
Fibromyalgia
Interventions
Drug: Pregabalin
First Posted Date
2006-06-29
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
357
Registration Number
NCT00346034
Locations
🇬🇧

Pfizer Investigational Site, Poole, United Kingdom

[S,S]-Reboxetine Add-On Trial

Phase 2
Terminated
Conditions
Pain
Interventions
Drug: [S,S]-Reboxetine + Pregabalin
Drug: Pregabalin
First Posted Date
2006-06-08
Last Posted Date
2019-12-16
Lead Sponsor
Pfizer
Target Recruit Count
136
Registration Number
NCT00334685
Locations
🇬🇧

Pfizer Investigational Site, York, United Kingdom

Randomized, Double-Blind, Placebo-Controlled Trial Of Pregabalin In Patients With Fibromyalgia.

Phase 3
Completed
Conditions
Fibromyalgia
Interventions
Drug: pregabalin
Drug: placebo
First Posted Date
2006-06-06
Last Posted Date
2021-02-11
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
747
Registration Number
NCT00333866
Locations
🇻🇪

Pfizer Investigational Site, Caracas, Estado Miranda, Venezuela

Efficacy Of Pregabalin In Subjects With Post-Stroke Central Neuropathic Pain

Phase 4
Completed
Conditions
Central Neuropathic Pain
Interventions
Drug: Placebo
Drug: Pregabalin
First Posted Date
2006-04-12
Last Posted Date
2021-02-09
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
220
Registration Number
NCT00313820
Locations
🇹🇭

Pfizer Investigational Site, Bangkok, Thailand

Effects of Pregabalin on Mechanical Hyperalgesia

First Posted Date
2006-04-04
Last Posted Date
2007-04-05
Lead Sponsor
Professional Associations Clinic Bergmannsheil
Target Recruit Count
120
Registration Number
NCT00310583
Locations
🇩🇪

Dept. of Anaesthesia and Transfusion Medicine, University of Tuebingen, Tuebingen, Germany

🇩🇪

Health Care Centre, Dept. of Neurology, Johannes Gutenberg University of Mainz, Mainz, Germany

🇩🇪

Interdisciplinary Dept. of Pain Management, Dept. of Anaesthesiology, Ludwig-Maximilians-University, Munich, Germany

and more 14 locations

A Study to Assess the Efficacy, Safety and Tolerability of Pregabalin in Patients With Symptoms of Neuropathic Pain

Phase 3
Completed
Conditions
Neuropathic Pain
First Posted Date
2006-03-10
Last Posted Date
2021-01-22
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
309
Registration Number
NCT00301223
Locations
🇨🇳

Pfizer Investigational Site, Tian Jin, China

P4 (Pregabalin for Peripheral Posttraumatic Pain)

Phase 4
Completed
Conditions
Neuralgia
Interventions
Drug: Placebo
Drug: pregabalin
First Posted Date
2006-02-15
Last Posted Date
2021-02-09
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
255
Registration Number
NCT00292188
Locations
🇬🇧

Pfizer Investigational Site, Plymouth, United Kingdom

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