Propranolol

Generic Name: Propranolol

Brand Names: Hemangeol, Hemangiol, Inderal, Innopran

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₁NO_₂

CAS Number: 525-66-6

Unique Ingredient Identifier: 9Y8NXQ24VQ

Background: Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

Propranolol was granted FDA approval on 13 November 1967.

Indication: Propranolol is indicated to treat hypertension. Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.

Associated Conditions: Akathisia caused by antipsychotic use, Angina Pectoris, Atrial Fibrillation, Cardiovascular Mortality, Essential Tremor, Gastroesophageal variceal hemorrhage prophylaxis, Hemangiomas, Hypertension, Migraine, Myocardial Infarction, Obstructive Hypertrophic Cardiomyopathy, Performance Anxiety, Pheochromocytoma, Proliferating Infantile Hemangioma, Supraventricular Arrhythmias, Tachyarrhythmia caused by Digitalis intoxication, Tachyarrhythmia caused by catecholamine excess, Thyroid Crisis, Thyrotoxicosis, Tremor caused by lithium, Ventricular Tachycardia (VT)

Associated Therapies: -

Clinical Trials

Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas

Phase 2

Terminated

Conditions: Hemangioma of Infancy

Interventions: Drug: propranolol
Drug: Prednisolone

First Posted Date: 2009-08-27

Last Posted Date: 2016-02-24

Lead Sponsor: Nancy Bauman

Target Recruit Count: 19

Registration Number: NCT00967226

Locations: 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States

Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding

Phase 4

Conditions: Variceal Bleeding
Cirrhosis

Interventions: Procedure: Endoscopic band ligation
Procedure: EBL+Propranolol
Drug: Propranolol

First Posted Date: 2009-08-26

Last Posted Date: 2017-08-23

Lead Sponsor: Korea University

Target Recruit Count: 288

Registration Number: NCT00965900

Locations: 🇰🇷
Korea University Anam Hospital, Seoul, Korea, Republic of

Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy

Conditions: Diabetes Mellitus
Arterial Hypertension

Interventions: Drug: Metformin
Drug: Glybenclamide
Drug: NPH insulin
Drug: Hydrochlorothiazide
Drug: Propranolol
Drug: Captopril
Drug: Amlodipine

First Posted Date: 2009-07-09

Last Posted Date: 2011-10-26

Lead Sponsor: Hospital de Clinicas de Porto Alegre

Target Recruit Count: 124

Registration Number: NCT00935805

Locations: 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

Burn Healing and Analgesia With Propranolol

Phase 2

Completed

Conditions: Pain
Burns

Interventions: Drug: Placebo
Drug: Propranolol
Drug: Propanolol

First Posted Date: 2009-07-08

Last Posted Date: 2017-11-17

Lead Sponsor: University of North Carolina, Chapel Hill

Target Recruit Count: 45

Registration Number: NCT00934947

Locations: 🇺🇸
Washington Hospital Center, Washington, D.C., District of Columbia, United States
🇺🇸
North Carolina Jaycee Burn Center, Chapel Hill, North Carolina, United States
🇺🇸
Crozer Chester Medical Center, Upland, Pennsylvania, United States

and more 1 locations