Ramelteon
- Generic Name
- Ramelteon
- Brand Names
- Rozerem
- Drug Type
- Small Molecule
- Chemical Formula
- C16H21NO2
- CAS Number
- 196597-26-9
- Unique Ingredient Identifier
- 901AS54I69
- Background
Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
- Indication
用于失眠症，特别适用于治疗难以入睡型失眠症。
- Associated Conditions
- Insomnia
- Associated Therapies
- -
Mechanisms of Sleep Latency and Health: The Effect of a Melatonin Receptor Agonist in Inflammation and Insulin Resistance
- First Posted Date
- 2014-06-05
- Last Posted Date
- 2015-07-28
- Lead Sponsor
- Duke University
- Target Recruit Count
- 75
- Registration Number
- NCT02156271
Ramelteon 8 mg Tablets Specified Drug-use Survey: <Long-term Survey on Insomnia Accompanied by Difficulty Falling Asleep> - Transitional Survey From the Preceding Drug-use Survey -
- First Posted Date
- 2014-06-02
- Last Posted Date
- 2016-10-13
- Lead Sponsor
- Takeda
- Target Recruit Count
- 236
- Registration Number
- NCT02153086
Ramelteon Tablets 8mg Drug Use Surveillance: Survey on Insomnia Associated With Sleep-onset Difficulty
- First Posted Date
- 2014-02-11
- Last Posted Date
- 2016-07-14
- Lead Sponsor
- Takeda
- Target Recruit Count
- 3339
- Registration Number
- NCT02058992
Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder
- First Posted Date
- 2012-08-31
- Last Posted Date
- 2016-03-16
- Lead Sponsor
- Takeda
- Target Recruit Count
- 535
- Registration Number
- NCT01677182
Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder
- First Posted Date
- 2011-07-25
- Last Posted Date
- 2011-07-25
- Lead Sponsor
- Sleep Medicine Centers of WNY
- Target Recruit Count
- 20
- Registration Number
- NCT01401413
- Locations
- 🇺🇸
Sleep Medicine Centers of WNY, West Seneca, New York, United States
Effect of Rozerem on Sleep Among People With Traumatic Brain Injury
- First Posted Date
- 2010-09-22
- Last Posted Date
- 2014-09-09
- Lead Sponsor
- Kessler Foundation
- Target Recruit Count
- 20
- Registration Number
- NCT01207050
- Locations
- 🇺🇸
Kessler Foundation Research Center, West Orange, New Jersey, United States
Treatment of Insomnia in Elderly Sleep Apnea Patients With Ramelteon (TAK 375)
- First Posted Date
- 2010-01-13
- Last Posted Date
- 2023-05-25
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 27
- Registration Number
- NCT01048242
- Locations
- 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Pharmacokinetic and Safety of Ramelteon Between Adolescents With Insomnia and Healthy Adults
- First Posted Date
- 2009-06-05
- Last Posted Date
- 2012-04-04
- Lead Sponsor
- Takeda
- Target Recruit Count
- 56
- Registration Number
- NCT00914862
Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon
- Conditions
- Interventions
- First Posted Date
- 2009-05-22
- Last Posted Date
- 2012-11-06
- Lead Sponsor
- Massachusetts General Hospital
- Registration Number
- NCT00907595
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep
- Conditions
- Interventions
- First Posted Date
- 2009-05-05
- Last Posted Date
- 2013-12-05
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 36
- Registration Number
- NCT00893269
- Locations
- 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States
Drug Development Updates
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