Riboflavin

Generic Name: Riboflavin

Brand Names: Alertonic, Concept Ob, Irospan 24/6 Kit, Mvc-fluoride, Natafort, Pregvit, Tandem Plus, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₀N_₄O_₆

CAS Number: 83-88-5

Unique Ingredient Identifier: TLM2976OFR

Background: Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Indication: For the treatment of ariboflavinosis (vitamin B2 deficiency).

Associated Conditions: Ariboflavinosis, Beriberi, Constipation, Functional Gastrointestinal Disorders (FGID), Joint Pain, Metabolic cardiomyopathy, Migraine, Myalgia, Neuropathic Pain, Peripheral neuritis, Peripheral paralysis, Vitamin B complex deficiency, Vitamin B1 deficiency, Vitamin Deficiency, Wernicke's encephalopathy

Associated Therapies: Dietary and Nutritional Therapies, Nutritional supplementation, Vitamin supplementation, Dietary supplementation

Clinical Trials

Effects of Riboflavin in Mitigating Muscle Soreness in Ultra-marathon Athletes

Early Phase 1

Recruiting

Conditions: Muscle Soreness

Interventions: Drug: Placebo
Drug: Riboflavin

First Posted Date: 2023-06-18

Last Posted Date: 2024-03-28

Lead Sponsor: Steven Moore

Target Recruit Count: 400

Registration Number: NCT05907850

Locations: 🇺🇸
The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Pack Cross Linking for Infectious Keratitis

Not Applicable

Not yet recruiting

Conditions: Infectoius Keratitis

Interventions: Drug: Riboflavin
Drug: Antibotice.g vigamox ED Antifungal e.g Dflucan
Device: pack cross linking

First Posted Date: 2023-05-31

Last Posted Date: 2023-05-31

Lead Sponsor: Sohag University

Target Recruit Count: 60

Registration Number: NCT05881187

Locations: 🇪🇬
Sohag University Hospital, Sohag, Egypt

Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia

Phase 3

Recruiting

Conditions: Corneal Ectasia
Keratoconus

Interventions: Drug: Riboflavin

First Posted Date: 2021-05-27

Last Posted Date: 2023-01-04

Lead Sponsor: Cornea and Laser Eye Institute

Target Recruit Count: 160

Registration Number: NCT04905108

Locations: 🇺🇸
Cornea and Laser Eye Institute, Hersh Vision Group, Teaneck, New Jersey, United States

Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose

Phase 3

Recruiting

Conditions: Keratoconus
Corneal Ectasia

Interventions: Drug: Riboflavin

First Posted Date: 2021-05-21

Last Posted Date: 2023-01-04

Lead Sponsor: Cornea and Laser Eye Institute

Target Recruit Count: 170

Registration Number: NCT04897503

Locations: 🇺🇸
Cornea and Laser Eye Institue - Hersh Vision Group, Teaneck, New Jersey, United States

Treating Corneal Thinning Conditions With CCL Vario Riboflavin (CXL)

Early Phase 1

Not yet recruiting

Conditions: Keratoconus, Unstable

Interventions: Drug: Riboflavin

First Posted Date: 2021-02-01

Last Posted Date: 2021-05-25

Lead Sponsor: Kent Wellish MD

Target Recruit Count: 600

Registration Number: NCT04731727

Riboflavin for Glutamate Reduction in Alcohol Withdrawal

Phase 2

Conditions: Nutrition Disorders
Alcohol Withdrawal
Alcohol Use Disorder

Interventions: Other: Placebo
Drug: Riboflavin

First Posted Date: 2020-01-18

Last Posted Date: 2021-09-29

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 40

Registration Number: NCT04232800

Investigating Oral Agents for Urine Staining to Facilitate Intraoperative Observation of Ureteral Jets

Early Phase 1

Completed

Conditions: Ureteral Injury

Interventions: Drug: Thiamine
Drug: Riboflavin
Drug: Pyridium

First Posted Date: 2018-02-14

Last Posted Date: 2020-08-11

Lead Sponsor: Texas Tech University Health Sciences Center

Target Recruit Count: 120

Registration Number: NCT03432572

Locations: 🇺🇸
Texas Tech University Health Sciences Center, Lubbock, Texas, United States

Accelerated Corneal Cross-linking With Different Riboflavin Solutions

Phase 3

Completed

Conditions: Keratoconus

Interventions: Drug: Riboflavin

First Posted Date: 2017-06-15

Last Posted Date: 2021-03-03

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 60

Registration Number: NCT03187912

Locations: 🇦🇹
Medical University of Vienna, Department of Ophthalmology, Vienna, Austria

Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit

Phase 1

Completed

Conditions: Keratolysis

Interventions: Drug: Riboflavin
Drug: Dextran
Device: UVA Light Source

First Posted Date: 2016-08-11

Last Posted Date: 2023-05-10

Lead Sponsor: Joseph B. Ciolino, MD

Target Recruit Count: 76

Registration Number: NCT02863809

Locations: 🇺🇸
UC Davis Health System Eye Center, Sacramento, California, United States
🇺🇸
The Jules Stein Eye Institute, Los Angeles, California, United States
🇺🇸
Shiley Eye Institute, University of California, San Diego, San Diego, California, United States

and more 10 locations

The Effect of Riboflavin on Moderate to Severe Plaque Type Psoriasis

Phase 2

Completed

Conditions: Psoriasis

Interventions: Drug: Riboflavin
Other: Placebo

First Posted Date: 2015-12-04

Last Posted Date: 2022-07-28

Lead Sponsor: University of Michigan

Target Recruit Count: 23

Registration Number: NCT02622386

Locations: 🇺🇸
University of Michigan Department of Dermatology, Ann Arbor, Michigan, United States

Drug Development Updates

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