Riboflavin

Generic Name: Riboflavin

Brand Names: Alertonic, Concept Ob, Irospan 24/6 Kit, Mvc-fluoride, Natafort, Pregvit, Tandem Plus, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₀N_₄O_₆

CAS Number: 83-88-5

Unique Ingredient Identifier: TLM2976OFR

Background: Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Indication: For the treatment of ariboflavinosis (vitamin B2 deficiency).

Associated Conditions: Ariboflavinosis, Beriberi, Constipation, Functional Gastrointestinal Disorders (FGID), Joint Pain, Metabolic cardiomyopathy, Migraine, Myalgia, Neuropathic Pain, Peripheral neuritis, Peripheral paralysis, Vitamin B complex deficiency, Vitamin B1 deficiency, Vitamin Deficiency, Wernicke's encephalopathy

Associated Therapies: Dietary and Nutritional Therapies, Nutritional supplementation, Vitamin supplementation, Dietary supplementation

Clinical Trials

Effects of Riboflavin in Mitigating Muscle Soreness in Ultra-marathon Athletes

Early Phase 1

Completed

Conditions: Muscle Soreness

Interventions: Drug: Placebo
Drug: Riboflavin

First Posted Date: 2023-06-18

Last Posted Date: 2025-04-03

Lead Sponsor: Steven Moore

Target Recruit Count: 150

Registration Number: NCT05907850

Locations: 🇺🇸
The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Pack Cross Linking for Infectious Keratitis

Not Applicable

Not yet recruiting

Conditions: Infectoius Keratitis

Interventions: Drug: Riboflavin
Drug: Antibotice.g vigamox ED Antifungal e.g Dflucan
Device: pack cross linking

First Posted Date: 2023-05-31

Last Posted Date: 2023-05-31

Lead Sponsor: Sohag University

Target Recruit Count: 60

Registration Number: NCT05881187

Locations: 🇪🇬
Sohag University Hospital, Sohag, Egypt

Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light

Phase 3

Recruiting

Conditions: Keratoconus
Corneal Ectasia

Interventions: Drug: riboflavin ophthalmic solution

First Posted Date: 2021-08-30

Last Posted Date: 2023-01-04

Lead Sponsor: Cornea and Laser Eye Institute

Target Recruit Count: 170

Registration Number: NCT05027295

Locations: 🇺🇸
Cornea and Laser Eye Institute, Hersh Vision Group, Teaneck, New Jersey, United States

Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia

Phase 3

Recruiting

Conditions: Corneal Ectasia
Keratoconus

Interventions: Drug: Riboflavin

First Posted Date: 2021-05-27

Last Posted Date: 2023-01-04

Lead Sponsor: Cornea and Laser Eye Institute

Target Recruit Count: 160

Registration Number: NCT04905108

Locations: 🇺🇸
Cornea and Laser Eye Institute, Hersh Vision Group, Teaneck, New Jersey, United States

Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose

Phase 3

Recruiting

Conditions: Keratoconus
Corneal Ectasia

Interventions: Drug: Riboflavin

First Posted Date: 2021-05-21

Last Posted Date: 2023-01-04

Lead Sponsor: Cornea and Laser Eye Institute

Target Recruit Count: 170

Registration Number: NCT04897503

Locations: 🇺🇸
Cornea and Laser Eye Institue - Hersh Vision Group, Teaneck, New Jersey, United States

Treating Corneal Thinning Conditions With CCL Vario Riboflavin (CXL)

Early Phase 1

Not yet recruiting

Conditions: Keratoconus, Unstable

Interventions: Drug: Riboflavin

First Posted Date: 2021-02-01

Last Posted Date: 2021-05-25

Lead Sponsor: Kent Wellish MD

Target Recruit Count: 600

Registration Number: NCT04731727

A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients

Not Applicable

Not yet recruiting

Conditions: Keratoconus

Interventions: Drug: Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light
Drug: Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light

First Posted Date: 2020-10-12

Last Posted Date: 2023-01-17

Lead Sponsor: Joseph B. Ciolino, MD

Target Recruit Count: 216

Registration Number: NCT04584125

Locations: 🇺🇸
Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States

Corneal Crosslinking Treatment Study

Phase 4

Completed

Conditions: Progressive Keratoconus

Interventions: Drug: Isotonic riboflavin
Drug: Hypotonic riboflavin
Procedure: Iontophoresis

First Posted Date: 2020-06-11

Last Posted Date: 2024-11-22

Lead Sponsor: Region Skane

Target Recruit Count: 54

Registration Number: NCT04427956

Locations: 🇸🇪
Skåne University Hospital, Lund, Skåne, Sweden

Riboflavin for Glutamate Reduction in Alcohol Withdrawal

Phase 2

Conditions: Nutrition Disorders
Alcohol Withdrawal
Alcohol Use Disorder

Interventions: Other: Placebo
Drug: Riboflavin

First Posted Date: 2020-01-18

Last Posted Date: 2021-09-29

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 40

Registration Number: NCT04232800

Steroids and Cross-linking for Ulcer Treatment

Phase 3

Completed

Conditions: Keratitis Bacterial

Interventions: Drug: Moxifloxacin Ophthalmic
Drug: Riboflavin Ophthalmic
Drug: Difluprednate Ophthalmic
Other: Topical Placebo

First Posted Date: 2019-09-20

Last Posted Date: 2025-02-03

Lead Sponsor: Thomas M. Lietman

Target Recruit Count: 280

Registration Number: NCT04097730

Locations: 🇮🇳
Aravind Eye Care System, Madurai, Tamil Nadu, India
🇺🇸
Francis I. Proctor Foundaiton, San Francisco, California, United States
🇺🇸
University of Miami, Miami, Florida, United States

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