Meropenem

Generic Name: Meropenem

Brand Names: Vabomere

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₅N_₃O_₅S

CAS Number: 96036-03-2

Unique Ingredient Identifier: YOP6PX0BAO

Background: Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
...

Indication: For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, vi...

Associated Conditions: Bacterial Infections, Complicated Intra-Abdominal Infections (cIAIs), Meningitis, Bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Complicated skin infection bacterial

Associated Therapies: -

Clinical Trials

Amplification and Selection of Antimicrobial Resistance in the Intestine II

Completed

Conditions: Antibiotic Selection Pressure

Interventions: Drug: meropenem

First Posted Date: 2017-05-04

Last Posted Date: 2020-08-03

Lead Sponsor: University Hospital Tuebingen

Target Recruit Count: 60

Registration Number: NCT03140826

Locations: 🇩🇪
Institute of Medical Microbiology and Hygiene, University Hospital of Tuebingen, Tuebingen, Germany
🇩🇪
University Hospital Cologne, Cologne, Germany

Glycocalyx Damage and Beta-lactam Antibiotics in Surgical Critically Ill

Completed

Conditions: Critical Illness

First Posted Date: 2017-05-02

Last Posted Date: 2018-10-24

Lead Sponsor: University Hospital Hradec Kralove

Target Recruit Count: 20

Registration Number: NCT03136796

Locations: 🇨🇿
University Hospital Hradec Kralove, Hradec Králové, Třebeš, Czechia

Computer-based Dosage Calculation for Antibiotics

Withdrawn

Conditions: Anti-Infective Agent Toxicity
Acute Kidney Insufficiency

Interventions: Drug: Piperacillin/tazobactam
Drug: Meropenem

First Posted Date: 2017-01-30

Last Posted Date: 2019-12-24

Lead Sponsor: University Hospital Tuebingen

Registration Number: NCT03036826

Locations: 🇩🇪
University Hospital Tuebingen, Tuebingen, Germany

Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens

Phase 3

Completed

Conditions: Healthcare-associated Pneumonia (HCAP)
Ventilator Associated Pneumonia (VAP)
Hospital Acquired Pneumonia (HAP)

Interventions: Drug: Cefiderocol
Drug: Meropenem
Drug: Linezolid

First Posted Date: 2017-01-26

Last Posted Date: 2020-11-13

Lead Sponsor: Shionogi

Target Recruit Count: 300

Registration Number: NCT03032380

Locations: 🇺🇦
Shionogi Research Site, Zaporizhzhya, Ukraine

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7079901 and the Combination of RO7079901 With Meropenem in Adult Healthy Volunteers

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: RO7079901
Other: RO7049389 Placebo
Other: Meropenem Placebo
Drug: Meropenem

First Posted Date: 2016-11-23

Last Posted Date: 2017-05-19

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 46

Registration Number: NCT02972255

Locations: 🇺🇸
Covance Clinical Research Unit Inc.; Covance Gfi Research, Evansville, Indiana, United States
🇺🇸
Covance Clinical Research Unit, Inc, Madison, Wisconsin, United States

LC-MS/MS Based Method Development for the Monitoring of Antibiotic Concentrations in Sputum of Cystic Fibrosis Patients

Not Applicable

Terminated

Conditions: Cystic Fibrosis

Interventions: Drug: Piperacillin-tazobactam combination product
Drug: Meropenem
Drug: Ceftazidime

First Posted Date: 2016-07-21

Last Posted Date: 2021-12-15

Lead Sponsor: University Ghent

Target Recruit Count: 40

Registration Number: NCT02840136

Locations: 🇧🇪
Ghent University, Ghent, Oost-Vlaanderen, Belgium

PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock

Phase 3

Conditions: Septic Shock

Interventions: Drug: MEROPENEM
Drug: PIPERACILLIN-TAZOBACTAM
Drug: CEFEPIME

First Posted Date: 2016-07-01

Last Posted Date: 2018-07-17

Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Target Recruit Count: 129

Registration Number: NCT02820987

Locations: 🇫🇷
Chu Besancon, Besançon, France

Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections

Phase 3

Completed

Conditions: Complicated Intra-abdominal Infections
Complicated Appendicitis

Interventions: Drug: Eravacycline
Drug: Meropenem
Drug: Placebo

First Posted Date: 2016-05-27

Last Posted Date: 2022-01-06

Lead Sponsor: Tetraphase Pharmaceuticals, Inc.

Target Recruit Count: 500

Registration Number: NCT02784704

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

Phase 2

Terminated

Conditions: Neoplasms
Febrile Neutropenia

Interventions: Drug: CAZ-AVI
Drug: Vancomycin
Drug: Linezolid
Drug: Cefepime
Drug: Meropenem
Drug: Piperacillin/tazobactam

First Posted Date: 2016-04-08

Last Posted Date: 2017-07-21

Lead Sponsor: Forest Laboratories

Target Recruit Count: 2

Registration Number: NCT02732327

Locations: 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States

The Pharmacodynamics of Meropenem in Patient With Ventilator-associated Pneumonia

Phase 4

Completed

Conditions: Ventilator-Associated Pneumonia

Interventions: Drug: Meropenem

First Posted Date: 2015-11-25

Last Posted Date: 2015-11-25

Lead Sponsor: Sutep Jaruratanasirikul

Target Recruit Count: 9

Registration Number: NCT02615041

Locations: 🇹🇭
Prince of Songkla University, Hatyai, Songkla, Thailand

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