Xylitol is a naturally occurring five-carbon sugar alcohol found in most plant material, including many fruits and vegetables. Xylitol-rich plant materials include birch and beechwood . It is widely used as a sugar substitute and in "sugar-free" food products. The effects of xylitol on dental caries have been widely studied, and xylitol is added to some chewing gums and other oral care products to prevent tooth decay and dry mouth. Xylitol is a non-fermentable sugar alcohol by most plaque bacteria, indicating that it cannot be fermented into cariogenic acid end-products . It works by inhibiting the growth of the microorganisms present in plaque and saliva after it accummulates intracellularly into the microorganism . The recommended dose of xylitol for dental caries prevention is 6–10 g/day, and most adults can tolerate 40 g/day without adverse events .
Indicated for use as a sugar substitute, and oral hygiene active ingredient.
Brigham and Women's Hospital, Boston, Massachusetts, United States
Taichung Veterans General Hospital, Taichung, None Selected, Taiwan
Brigham and Women's Hospital, Boston, Massachusetts, United States
JSS Dental College & Hospital, Mysore, Karnataka, India
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Ochsner Medical Center, New Orleans, Louisiana, United States
The University of Texas Health Science Center at Houston, Houston, Texas, United States
King abulaziz University, Dental University Hospital, Jeddah, P.O Box 80209, Saudi Arabia
Northwestern University, Chicago, Illinois, United States
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
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