MedPath

Xylitol

Generic Name
Xylitol
Drug Type
Small Molecule
Chemical Formula
C5H12O5
CAS Number
87-99-0
Unique Ingredient Identifier
VCQ006KQ1E
Background

Xylitol is a naturally occurring five-carbon sugar alcohol found in most plant material, including many fruits and vegetables. Xylitol-rich plant materials include birch and beechwood . It is widely used as a sugar substitute and in "sugar-free" food products. The effects of xylitol on dental caries have been widely studied, and xylitol is added to some chewing gums and other oral care products to prevent tooth decay and dry mouth. Xylitol is a non-fermentable sugar alcohol by most plaque bacteria, indicating that it cannot be fermented into cariogenic acid end-products . It works by inhibiting the growth of the microorganisms present in plaque and saliva after it accummulates intracellularly into the microorganism . The recommended dose of xylitol for dental caries prevention is 6–10 g/day, and most adults can tolerate 40 g/day without adverse events .

Indication

Indicated for use as a sugar substitute, and oral hygiene active ingredient.

Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients with Inflammatory Bowel Disease

Early Phase 1
Not yet recruiting
Conditions
Inflammatory Bowel Disease (IBD)
Clostridioides Difficile Infection
Interventions
First Posted Date
2025-01-29
Last Posted Date
2025-02-14
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
180
Registration Number
NCT06799039
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Efficacy and Safety of Xylitol Nasal Irrigation After Functional Endoscopic Sinus Surgery

Not Applicable
Completed
Conditions
Chronic Rhinosinusitis
Postoperative Care
Interventions
Drug: Salt Powder
First Posted Date
2023-10-31
Last Posted Date
2023-10-31
Lead Sponsor
Taichung Veterans General Hospital
Target Recruit Count
79
Registration Number
NCT06108921
Locations
🇨🇳

Taichung Veterans General Hospital, Taichung, None Selected, Taiwan

Xylitol Use for Decolonization of C. Difficile in Patients With IBD

Phase 1
Not yet recruiting
Conditions
Inflammatory Bowel Diseases
Clostridioides Difficile Infection
Interventions
Drug: Placebo
First Posted Date
2023-05-10
Last Posted Date
2024-05-13
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
99
Registration Number
NCT05852587
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk

Phase 2
Completed
Conditions
Mouthwashes
Cariostatic Agents
Interventions
First Posted Date
2020-05-22
Last Posted Date
2020-07-22
Lead Sponsor
Dr. Krupa NC
Target Recruit Count
60
Registration Number
NCT04399161
Locations
🇮🇳

JSS Dental College & Hospital, Mysore, Karnataka, India

Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Patients

Phase 2
Terminated
Conditions
Allogeneic Hematopoietic Cell Transplantation
Interventions
Other: Placebo
First Posted Date
2019-10-07
Last Posted Date
2023-02-08
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
46
Registration Number
NCT04117477
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Xylitol for Chronic Sinusitis

Phase 2
Completed
Conditions
Drain Sinus
Chronic Rhinosinusitis
Rhinosinusitis
Sinusitis
Endoscopic Sinus Surgery
Biofilms
Bacterial Overgrowth
Interventions
Drug: Saline
First Posted Date
2017-07-25
Last Posted Date
2023-04-07
Lead Sponsor
Ochsner Health System
Target Recruit Count
1
Registration Number
NCT03229551
Locations
🇺🇸

Ochsner Medical Center, New Orleans, Louisiana, United States

Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis

Phase 4
Completed
Conditions
Gingivitis
Plaque, Dental
Periodontal Diseases
Interventions
First Posted Date
2017-07-18
Last Posted Date
2021-02-08
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
70
Registration Number
NCT03219840
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

Xylitol for Otitis Media

Phase 2
Withdrawn
Conditions
Otitis Media With Effusion
Interventions
Other: Intranasal saline spray
First Posted Date
2016-11-01
Last Posted Date
2017-12-22
Lead Sponsor
Duke University
Registration Number
NCT02950311

Impact of Maternal Xylitol Consumption on Mutans Sterptococci

Phase 4
Completed
Conditions
Dental Caries and Streptococcus Mutans Count
Interventions
Drug: fluoride varnish application
First Posted Date
2014-01-14
Last Posted Date
2014-01-14
Lead Sponsor
King Abdulaziz University
Target Recruit Count
60
Registration Number
NCT02036151
Locations
🇸🇦

King abulaziz University, Dental University Hospital, Jeddah, P.O Box 80209, Saudi Arabia

Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis

Phase 1
Completed
Conditions
Cystic Fibrosis
Interventions
Drug: Hypertonic saline
First Posted Date
2011-05-18
Last Posted Date
2018-10-24
Lead Sponsor
Joseph Zabner
Target Recruit Count
30
Registration Number
NCT01355796
Locations
🇺🇸

Northwestern University, Chicago, Illinois, United States

🇺🇸

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States

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