Cetylpyridinium chloride
- Generic Name
- Cetylpyridinium chloride
- Brand Names
- Cepacol Antibacterial Mouthwash, Crest Mouthwash, Orajel Bleeding Gum Rinse, Orasep Reformulated Dec 2013
- Drug Type
- Small Molecule
- Chemical Formula
- C21H38N
- CAS Number
- 7773-52-6
- Unique Ingredient Identifier
- CUB7JI0JV3
- Background
Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties. Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis.
- Indication
Typically employed as the cetylpyridinium chloride salt, this compound is commonly used as an active ingredient in various over-the-counter mouthwashes, toothpastes, lozenges, and mouth sprays where it is generally indicated for antiseptic actions, gingivitis and plaque prevention, as well as action or prevention against some other oropharyngeal bacterial infections .
- Associated Conditions
- Gingivitis, Oral Pain, Pain, Orofacial, Sore Throat, Stomatitis, Teething pain, Throat irritation, Dry cough, Gum pain, Oral discomfort and pain, Oral infections, Pain in throat, Throat infections, Throat inflammation
- Associated Therapies
- Disinfection, Oral antisepsis, Oral disinfection
Clinical Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC)
- Conditions
- Dental PlaqueDental Plaque Induced GingivitisDental Plaque and GingivitisGingivitis
- Interventions
- Device: oral irrigator
- First Posted Date
- 2024-09-23
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Colgate Palmolive
- Target Recruit Count
- 30
- Registration Number
- NCT06607172
- Locations
- 🇧🇷
Federal University of Pelotas, Pelotas, RS, Brazil
Effect of Mouthwash in Reducing the Symptoms Associated With Flu and Cold Viruses
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2024-06-28
- Last Posted Date
- 2024-06-28
- Lead Sponsor
- Colgate Palmolive
- Target Recruit Count
- 150
- Registration Number
- NCT06479226
- Locations
- 🇧🇷
Federal University of Pelotas, Pelotas, Rio Grande Do Sul, Brazil
Salivary Drug Concentration Exploratory Study of Cetylpyridinium Chloride Buccal Tablets
- Conditions
- Pharyngitis AcuteGingivitis
- Interventions
- First Posted Date
- 2023-04-06
- Last Posted Date
- 2023-07-12
- Lead Sponsor
- Peking University People's Hospital
- Target Recruit Count
- 10
- Registration Number
- NCT05802628
- Locations
- 🇨🇳
Peking University People's Hospital, Beijing, Beijing, China
The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
- Conditions
- MouthwashesSARS-CoV-2Viral LoadPolymerase Chain ReactionCoronavirusSalivaCOVID-19Covid19
- Interventions
- First Posted Date
- 2021-01-22
- Last Posted Date
- 2022-07-21
- Lead Sponsor
- King Abdulaziz University
- Target Recruit Count
- 90
- Registration Number
- NCT04721457
- Locations
- 🇸🇦
Alhamra TETAMMAN clinic (PHC), Jeddah, Saudi Arabia
Mouth Rinses for Inactivation of COVID-19
- Conditions
- Covid19Coronavirus InfectionSARS-CoV-2 Infection
- Interventions
- Other: 0.9% w/v NaCL SalineDrug: 0.5% w/v Povidone-iodideDrug: 0.12% Chlorohexidine Gluconate
- First Posted Date
- 2020-10-14
- Last Posted Date
- 2024-03-25
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 128
- Registration Number
- NCT04584684
- Locations
- 🇺🇸
General and Oral Health Center, Chapel Hill, North Carolina, United States
A Novel Mouthwash Formulation CTP/BNZ With Mucus Adhesive Polymer
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2018-10-16
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
- Target Recruit Count
- 26
- Registration Number
- NCT03706781
- Locations
- 🇨🇭
CROSS Research S.A., Phase I Unit, Via F.A. Giorgioli 14 Phone: Fax: +41.91.63.00.511 Email:, Arzo, Switzerland
Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
- Conditions
- GingivitisPlaque, DentalPeriodontal Diseases
- Interventions
- First Posted Date
- 2017-07-18
- Last Posted Date
- 2021-02-08
- Target Recruit Count
- 70
- Registration Number
- NCT03219840
- Locations
- 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States
Mouthwashes During Orthodontic Treatment
- Conditions
- Gingivitis
- Interventions
- First Posted Date
- 2017-06-07
- Last Posted Date
- 2017-06-07
- Lead Sponsor
- University of Taubate
- Target Recruit Count
- 60
- Registration Number
- NCT03179735
- Locations
- 🇧🇷
Nucleus of periodontal research of University of Taubate, Taubate, SP, Brazil
Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal
- Conditions
- Premature Birth of NewbornPeriodontitis
- Interventions
- First Posted Date
- 2016-06-02
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 175
- Registration Number
- NCT02788786
- Locations
- 🇳🇵
Nepal Nutrition Intervention Project, Hariaun, Sarlahi District, Nepal
A Comparison of Mouth Rinse Containing Alcohol-free Chlorhexidine With a Cetylpyridinium Chloride in Periodontal Diseases
- Conditions
- Periodontal Diseases
- Interventions
- First Posted Date
- 2016-04-29
- Last Posted Date
- 2016-05-02
- Lead Sponsor
- Islamic Azad University, Tehran
- Target Recruit Count
- 34
- Registration Number
- NCT02756377
Drug Development Updates
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