Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Perioperative Analgesia Using Ultrasound (US) Guided Transversus Abdominis Plane (TAP) Block

Early Phase 1

Conditions: Postoperative Pain

Interventions: Drug: Bupivacaine
Other: TAP

First Posted Date: 2009-01-09

Last Posted Date: 2015-09-15

Lead Sponsor: King Saud University

Target Recruit Count: 42

Registration Number: NCT00819962

Locations: 🇸🇦
A Dawlatly, Riyadh, Saudi Arabia

Phase 3 Study of Local Administration of SKY0402 for Postoperative Analgesia in Subject Undergoing Breast Augmentation

Phase 3

Terminated

Conditions: Pain

Interventions: Drug: SKY0402
Drug: Bupivacaine HCl

First Posted Date: 2008-12-22

Last Posted Date: 2014-01-16

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 136

Registration Number: NCT00813111

Locations: 🇺🇸
Miami Plastic Surgery, Miami, Florida, United States
🇺🇸
The Ohio State University Research Foundation, Columbus, Ohio, United States
🇺🇸
West Alabama Research, LLC., Birmingham, Alabama, United States

and more 12 locations

Does Bupivacaine in Laparoscopic Portals Reduce Post Surgery Pain in Tubal Ligation by Electrocoagulation?

Not Applicable

Conditions: Pain

Interventions: Drug: Saline solution (laparoscopic tubal ligation)
Drug: Bupivacaine

First Posted Date: 2008-12-18

Last Posted Date: 2009-08-28

Lead Sponsor: Hospital de Clinicas de Porto Alegre

Target Recruit Count: 46

Registration Number: NCT00810563

Locations: 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

Spinal Anesthesia for Cesarean Delivery: Bupivacaine With or Without Fentanyl

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Bupivacaine, fentanyl
Drug: Bupivacaine

First Posted Date: 2008-12-15

Last Posted Date: 2009-11-20

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 140

Registration Number: NCT00808327

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Dose Finding Posterolateral Thoracotomy Study

Phase 2

Terminated

Conditions: Postoperative Pain

Interventions: Drug: High Dose SKY0402
Drug: Placebo
Drug: Low Dose SKY0402
Drug: Fentanyl via PCA
Drug: Bupivacaine via epidural

First Posted Date: 2008-12-11

Last Posted Date: 2012-05-15

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 3

Registration Number: NCT00807209

Locations: 🇺🇸
Multicare Health System, Tacoma, Washington, United States
🇺🇸
Florida Hospital, Orlando, Florida, United States
🇺🇸
Lotus Clinical Research, Pasadena, California, United States

and more 2 locations