Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

ICNBs for Post-op Pain in Breast Surgery

Phase 4

Conditions: Pain, Postoperative
Length of Stay

Interventions: Drug: Bupivacaine Hydrochloride

First Posted Date: 2020-10-28

Last Posted Date: 2020-12-09

Lead Sponsor: Christine M. Kleinert Institute for Hand and Microsurgery

Target Recruit Count: 40

Registration Number: NCT04606836

Locations: 🇺🇸
Christine M Kleinert Institute for Hand and Microsurgery, Louisville, Kentucky, United States
🇺🇸
Ambulatory Surgery Center, Kleinert Kutz Hand Care Center, New Albany, Indiana, United States
🇺🇸
Baptist Health Floyd, New Albany, Indiana, United States

and more 2 locations

Liposomal Bupivacaine vs Bupivacaine for Pain Control After Sternotomy

Phase 1

Conditions: Sternotomy
Pain Management

Interventions: Drug: Exparel
Drug: Bupivacaine

First Posted Date: 2020-10-14

Last Posted Date: 2020-10-14

Lead Sponsor: University of Kansas Medical Center

Target Recruit Count: 80

Registration Number: NCT04585867

Locations: 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States

Serratus Anterior Block and Erector Spinae Block in Postoperative Analgesia

Not Applicable

Completed

Conditions: Postoperative Analgesia

Interventions: Procedure: Serratus anterior block (SAB)
Procedure: Erector spinae block
Drug: Saline (as a placebo)
Drug: Bupivacaine

First Posted Date: 2020-10-08

Last Posted Date: 2021-03-09

Lead Sponsor: National Cancer Institute, Egypt

Target Recruit Count: 90

Registration Number: NCT04579302

Locations: 🇪🇬
National Cancer Institute, Cairo, Egypt

Periarticular Injection Versus Popliteal Block

Phase 4

Conditions: Foot Surgery
Ankle Surgery

Interventions: Drug: Exparel
Drug: Bupivicaine

First Posted Date: 2020-10-05

Last Posted Date: 2024-08-21

Lead Sponsor: Campbell Clinic

Target Recruit Count: 100

Registration Number: NCT04575688

Locations: 🇺🇸
A, Germantown, Tennessee, United States

Peribulbar Block for Prevention of Oculocardiac Reflex

Phase 4

Conditions: Strabismus

Interventions: Drug: Bupivacaine

First Posted Date: 2020-09-16

Last Posted Date: 2020-09-16

Lead Sponsor: Fayoum University Hospital

Target Recruit Count: 70

Registration Number: NCT04549844

Locations: 🇪🇬
Faculty of Medicine -Fayoum University, Fayoum, Egypt

Efficacy Of Magnesium In Radicular Pain When Added To Local Anesthetics And Steroids In Transforaminal Epidural Injection

Phase 1

Conditions: Pain
Neuropathy

Interventions: Drug: magnesium
Drug: Methylprednisolone
Drug: Bupivacaine Hydrochloride
Drug: saline 0.9%

First Posted Date: 2020-08-31

Last Posted Date: 2020-08-31

Lead Sponsor: Fayoum University

Target Recruit Count: 100

Registration Number: NCT04532775

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

Phase 3

Completed

Conditions: Metatarsophalangeal Fushion
Lower Extremity Surgery
Midfoot Fusion
Total Ankle Arthroplasty
Bunion
Hindfoot Fushion

Interventions: Drug: Exparel
Drug: Bupivacaine Hydrochloride

First Posted Date: 2020-08-19

Last Posted Date: 2022-07-18

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 121

Registration Number: NCT04518462

Locations: 🇺🇸
Lotus Clinical Research, Pasadena, California, United States
🇺🇸
HD Research, Corp, Bellaire, Texas, United States
🇺🇸
Arizona Research Center, Phoenix, Arizona, United States

and more 2 locations