Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2018-08-31
- Last Posted Date
- 2020-11-03
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 99
- Registration Number
- NCT03653416
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Onset and Duration of Forearm Nerve Blockade
- First Posted Date
- 2018-08-28
- Last Posted Date
- 2019-02-26
- Lead Sponsor
- New York School of Regional Anesthesia
- Target Recruit Count
- 36
- Registration Number
- NCT03649763
- Locations
- 🇧🇪
Ziekenhuis Oost-Limburg, Genk, Limburg, Belgium
The Effect of Pre-sacral Nerve Block on Immediate Post-operative Pain Following Laparoscopic Hysterectomy.
- First Posted Date
- 2018-08-24
- Last Posted Date
- 2018-08-27
- Lead Sponsor
- Mount Sinai Hospital, Canada
- Target Recruit Count
- 60
- Registration Number
- NCT03646006
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Epidural Analgesia and Postoperative Respiratory Functions (EPAPRES)
- Conditions
- Interventions
- First Posted Date
- 2018-08-23
- Last Posted Date
- 2018-08-23
- Lead Sponsor
- Yedikule Training and Research Hospital
- Target Recruit Count
- 62
- Registration Number
- NCT03643757
Efficacy Between Serratus Plane Block And Local Infiltration In Vats
- First Posted Date
- 2018-08-22
- Last Posted Date
- 2020-09-30
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 65
- Registration Number
- NCT03642457
- Locations
- 🇺🇸
Mount Sinai West Hospital, New York, New York, United States
🇺🇸Mount Sinai St. Luke's Hospital, New York, New York, United States
Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy
- Conditions
- Interventions
- First Posted Date
- 2018-08-21
- Last Posted Date
- 2022-06-22
- Lead Sponsor
- Karolinska Institutet
- Target Recruit Count
- 211
- Registration Number
- NCT03639389
- Locations
- 🇸🇪
Karolinska Hospital, Solna, Stockholm, Sweden
🇸🇪Capio St Görans Hospital, Stockholm, Sweden
Interscalene Single Shot With Plain Bupivacaine Versus Liposomal Bupivacaine for Arthroscopic Shoulder Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-08-20
- Last Posted Date
- 2024-04-15
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 40
- Registration Number
- NCT03638960
- Locations
- 🇺🇸
University of Southern California, Los Angeles, California, United States
Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients
- Conditions
- Interventions
- First Posted Date
- 2018-08-20
- Last Posted Date
- 2019-09-09
- Lead Sponsor
- Inova Health Care Services
- Target Recruit Count
- 63
- Registration Number
- NCT03638635
- Locations
- 🇺🇸
Inova Fairfax Medical Campus, Falls Church, Virginia, United States
🇺🇸Fairfax Colon & Rectal Surgery, Fair Oaks Office, Fairfax, Virginia, United States
🇺🇸Fairfax Colon & Rectal Surgery, Loudoun Office, Lansdowne Town Center, Virginia, United States
A Comparison of the Post-C/S Analgesic Effects of Neuraxial Duramorph vs Bilateral TAP Block With Liposomal Bupivacaine
- First Posted Date
- 2018-08-20
- Last Posted Date
- 2022-06-07
- Lead Sponsor
- Maimonides Medical Center
- Target Recruit Count
- 71
- Registration Number
- NCT03638011
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
🇺🇸Kalpana Tyagaraj, Brooklyn, New York, United States
Evaluation of Diaphragm Movement After an Interscalene Block
- Conditions
- Interventions
- First Posted Date
- 2018-08-17
- Last Posted Date
- 2022-11-30
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 26
- Registration Number
- NCT03636542
- Locations
- 🇺🇸
Univeristy of Minnesota, Minneapolis, Minnesota, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.