Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Dexmedetomidine Versus Clonidine for Transversus Abdominis Plane Block in Patients Undergoing Elective Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2018-12-10
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT03770013
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
EXPAREL for Minimally Invasive Supracervical Hysterectomies
- First Posted Date
- 2018-12-07
- Last Posted Date
- 2024-01-09
- Lead Sponsor
- Maimonides Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT03769714
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
Role of Dexamethasone in Transversus Abdominis Plane Block After Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2018-12-07
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT03767920
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
- First Posted Date
- 2018-11-29
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 46
- Registration Number
- NCT03757715
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
Erector Spinae Plane Block For Lumbar Disc Hernia Repair
- Conditions
- Interventions
- First Posted Date
- 2018-11-16
- Last Posted Date
- 2020-02-05
- Lead Sponsor
- Kocaeli University
- Target Recruit Count
- 60
- Registration Number
- NCT03744689
- Locations
- 🇹🇷
Kocaeli University, Kocaeli, Turkey
Spinal Anesthesia in Caesarean Section
- First Posted Date
- 2018-11-16
- Last Posted Date
- 2021-07-21
- Target Recruit Count
- 250
- Registration Number
- NCT03743870
- Locations
- 🇮🇹
"G. Rodolico" Presidium of the Azienda Ospedaliero Universitaria "Policlinico-Vittorio Emanuele", Catania, Italy
Exparel for Total Shoulder Pain
- First Posted Date
- 2018-11-13
- Last Posted Date
- 2019-07-16
- Lead Sponsor
- University of South Florida
- Target Recruit Count
- 60
- Registration Number
- NCT03739021
Liposomal Bupivacaine in Rotator Cuff Repair
- First Posted Date
- 2018-11-13
- Last Posted Date
- 2024-05-16
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 64
- Registration Number
- NCT03738696
- Locations
- 🇺🇸
UAB Hospital-Highlands, Birmingham, Alabama, United States
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
- Conditions
- Interventions
- First Posted Date
- 2018-11-09
- Last Posted Date
- 2024-05-24
- Lead Sponsor
- Milton S. Hershey Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT03737292
- Locations
- 🇺🇸
Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: A Sequential Allocation Trial to Determine the Optimum Interval Time Between Boluses of a Fixed Volume of 2.5ml of Bupivacaine 0.25% Plus Fentanyl 8 mcg/ml
- First Posted Date
- 2018-11-08
- Last Posted Date
- 2019-11-08
- Target Recruit Count
- 20
- Registration Number
- NCT03735771
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.