Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty

Phase 4

Completed

Conditions: Pain, Postoperative
Urethral Stricture

Interventions: Drug: Oxycodone
Drug: Acetaminophen
Drug: Ibuprofen 800 mg
Drug: Gabapentin
Drug: celebrex
Drug: Bupivacaine
Drug: Dexamethasone

First Posted Date: 2019-03-01

Last Posted Date: 2023-08-01

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 60

Registration Number: NCT03859024

Locations: 🇺🇸
University of Alabama of Birmingham, Birmingham, Alabama, United States

Unilateral TAP Block for Laparoscopic Gastric Sleeve Surgery

Phase 4

Completed

Conditions: Subcostal Transversus Abdominis Plane Block
Laparoscopic Sleeve Gastrectomy

Interventions: Drug: Saline
Drug: Bupivacaine

First Posted Date: 2019-02-27

Last Posted Date: 2022-10-17

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 43

Registration Number: NCT03856788

Locations: 🇺🇸
Mount Sinai Brooklyn, New York, New York, United States

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

Phase 4

Recruiting

Conditions: Burns
Pain, Postoperative

Interventions: Drug: Liposomal bupivacaine
Drug: Lidocaine Hydrochloride
Drug: Bupivacaine Hydrochloride

First Posted Date: 2019-02-26

Last Posted Date: 2024-05-01

Lead Sponsor: University of Kansas Medical Center

Target Recruit Count: 75

Registration Number: NCT03854344

Locations: 🇺🇸
The University of Kansas Health System, Kansas City, Kansas, United States

Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.

Not Applicable

Conditions: Postoperative Pain
Emergence Agitation

Interventions: Drug: Bupivacaine
Drug: Magnesium sulfate 30 mg
Drug: Magnesium sulfate 50mg

First Posted Date: 2019-02-19

Last Posted Date: 2019-02-19

Lead Sponsor: Mansoura University

Target Recruit Count: 93

Registration Number: NCT03846284

Locations: 🇪🇬
Marwa ibrahim mohamed abdo, Mansourah, Egypt

A Study to Evaluate Safety, PK, Efficacy of TLC590 for Postsurgical Pain Management Following Bunionectomy

Phase 2

Completed

Conditions: Hallux Valgus

Interventions: Drug: TLC590
Drug: Naropin®
Drug: Normal Saline
Drug: Bupivacaine

First Posted Date: 2019-02-12

Last Posted Date: 2020-04-07

Lead Sponsor: Taiwan Liposome Company

Target Recruit Count: 150

Registration Number: NCT03838133

Locations: 🇺🇸
Chesapeake Research Group, Pasadena, Maryland, United States
🇺🇸
JBR clinical research, Draper, Utah, United States
🇺🇸
Arizona Research Center, Phoenix, Arizona, United States

and more 2 locations

Bupivacaine 5 mg vs 7.5 mg for Spinal Anesthesia in Cesarean Delivery in Indonesian Population

Not Applicable

Completed

Conditions: Hypotension Drug-Induced
Spinal Anesthesia
Postoperative Complications
Cesarean Section

Interventions: Drug: Bupivacaine

First Posted Date: 2019-02-08

Last Posted Date: 2019-02-11

Lead Sponsor: Indonesia University

Target Recruit Count: 112

Registration Number: NCT03834454

Locations: 🇮🇩
Cipto Mangunkusumo Hospital, Jakarta Pusat, DKI Jakarta, Indonesia

Regional Anesthesia Versus General Anesthesia

Not Applicable

Completed

Conditions: Postoperative Pain
Anesthesia

Interventions: Drug: Midazolam
Drug: Sufentanil
Drug: Bupivacaine
Drug: Propofol
Drug: Rocuronium
Drug: Sevoflurane

First Posted Date: 2019-02-05

Last Posted Date: 2019-07-15

Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Target Recruit Count: 28

Registration Number: NCT03830086

Locations: 🇮🇹
Cardiothoracic and Vascular Anesthesia and Intensive Care, S. OrsolaMalpighi University Hospital, Bologna, BO, Italy
🇮🇹
Gynecology and Physiopathology of Human Reproductive Unit, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, BO, Italy