Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Optimizing Anesthesia for Post Partum Tubal Ligations
- First Posted Date
- 2019-06-20
- Last Posted Date
- 2021-12-17
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 15
- Registration Number
- NCT03993314
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
Comparison of Analgesic Efficacy Between of Interscalene Block With Liposomal Bupivacaine With Bupivacaine and Dexamethasone
- First Posted Date
- 2019-05-31
- Last Posted Date
- 2024-05-07
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 90
- Registration Number
- NCT03969875
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
To Evaluate the Effect of Wound Infiltration With Bupivacaine for Post-operative Pain Relief After Laparoscopic Cholecystectomy
- First Posted Date
- 2019-05-22
- Last Posted Date
- 2020-06-01
- Target Recruit Count
- 58
- Registration Number
- NCT03958513
- Locations
- 🇧🇩
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Analgesic Efficacy of Fascia Iliaca Compartment Block
- Conditions
- Interventions
- First Posted Date
- 2019-05-21
- Last Posted Date
- 2019-05-21
- Lead Sponsor
- Samaa Rashwan
- Target Recruit Count
- 60
- Registration Number
- NCT03957499
- Locations
- 🇪🇬
Beni-Suef University Hospital, Banī Suwayf, Egypt
EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture
- Conditions
- Interventions
- First Posted Date
- 2019-05-20
- Last Posted Date
- 2020-02-27
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Registration Number
- NCT03955458
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries
- First Posted Date
- 2019-05-17
- Last Posted Date
- 2020-08-13
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Registration Number
- NCT03954639
Erector Spinae Plane Block for Congenital Hip Dislocation Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-05-14
- Last Posted Date
- 2020-07-22
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 60
- Registration Number
- NCT03949686
- Locations
- 🇹🇷
Ataturk University, Erzurum, Turkey
Liposomal Bupivacaine Versus Interscalene Nerve Block
- Conditions
- Interventions
- First Posted Date
- 2019-04-26
- Last Posted Date
- 2023-05-10
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 76
- Registration Number
- NCT03929146
- Locations
- 🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States
Intranasal Injection of Dexmedetomidine and Bupivacaine in Septoplasty Surgeries
- Conditions
- Interventions
- First Posted Date
- 2019-04-24
- Last Posted Date
- 2019-08-01
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 40
- Registration Number
- NCT03926663
- Locations
- 🇪🇬
Faculty of medicine,Beni-Suef University, Banī Suwayf, Egypt
Pediatric Postoperative Analgesia Herniorrhaphy Study
- Conditions
- Interventions
- First Posted Date
- 2019-04-19
- Last Posted Date
- 2023-06-05
- Lead Sponsor
- Heron Therapeutics
- Registration Number
- NCT03922048
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.