Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
The Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Pain in Laparoscopic Cholecystectomy
- Conditions
- Interventions
- First Posted Date
- 2020-01-28
- Last Posted Date
- 2020-09-03
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 56
- Registration Number
- NCT04244097
- Locations
- 🇪🇬
Sara Farouk Kassem Habib, Cairo, El Azbakeya, Egypt
Bupivacaine Levels After ESPB
- First Posted Date
- 2020-01-23
- Last Posted Date
- 2022-04-05
- Lead Sponsor
- Maltepe University
- Target Recruit Count
- 17
- Registration Number
- NCT04239053
- Locations
- 🇹🇷
Maltepe University Medical Faculty, Istanbul, Maltepe, Turkey
Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section
- Conditions
- Interventions
- First Posted Date
- 2020-01-18
- Last Posted Date
- 2024-04-10
- Lead Sponsor
- Wake Forest University Health Sciences
- Registration Number
- NCT04232306
- Locations
- 🇺🇸
Atrium Health, Charlotte, North Carolina, United States
Quadratus Lumborum Block for Congenital Hip Dislocation Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-12-30
- Last Posted Date
- 2019-12-30
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 40
- Registration Number
- NCT04212832
- Locations
- 🇹🇷
Ataturk University, Erzurum, Yakutiye, Turkey
Pericapsular Nerve Group (PENG) Block for Congenital Hip Dislocation Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-12-26
- Last Posted Date
- 2022-09-13
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 48
- Registration Number
- NCT04212039
- Locations
- 🇹🇷
Ataturk University, Erzurum, Turkey
Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block
- Conditions
- Interventions
- First Posted Date
- 2019-12-24
- Last Posted Date
- 2024-01-29
- Lead Sponsor
- Duke University
- Target Recruit Count
- 60
- Registration Number
- NCT04209504
- Locations
- 🇺🇸
Duke University Hospital, Durham, North Carolina, United States
Efficacy of Repeated Locoregional Anesthetics Blocks With Bupivacaine in Patients Suffering of Chronic Dentoalveolar Pain.
- First Posted Date
- 2019-12-20
- Last Posted Date
- 2020-08-31
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Target Recruit Count
- 50
- Registration Number
- NCT04207411
- Locations
- 🇫🇷
CHU de Clermont-Ferrand, Clermont-Ferrand, France
End Tidal Anesthetic Concentration in Different Anesthesia Techniques Where Depth of Anesthesia Adjusted With Entropy
- Conditions
- Interventions
- First Posted Date
- 2019-12-18
- Last Posted Date
- 2022-03-17
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 44
- Registration Number
- NCT04203290
- Locations
- 🇹🇷
İstanbul University, Istanbul, Turkey
A Comparison of 4% Articaine Versus 0.5%Bupivacaine for Ambulatory Surgery Under Supraclavicular Block
- Conditions
- Interventions
- First Posted Date
- 2019-12-06
- Last Posted Date
- 2020-04-28
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT04189198
- Locations
- 🇪🇬
Ain Shams University hosptal, Cairo, Abbasya, Egypt
Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2019-11-22
- Last Posted Date
- 2021-05-06
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 20
- Registration Number
- NCT04173611
- Locations
- 🇺🇸
Duke University, Durham, North Carolina, United States
Drug Development Updates
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