Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section

Not Applicable

Conditions: Analgesia

Interventions: Drug: sufentanil
Drug: meperidine
Drug: Bupivacaine

First Posted Date: 2020-06-25

Last Posted Date: 2021-07-30

Lead Sponsor: Makassed General Hospital

Target Recruit Count: 60

Registration Number: NCT04446715

Locations: 🇱🇧
Makassed General Hospital, Beirut, Lebanon

Caudal Epidural With Non Opioid Adjuvants in Lumbosacral Spine Surgery

Not Applicable

Completed

Conditions: Caudal Analgesia for Lumosacral Spine Surgeries

Interventions: Drug: Bupivacaine
Drug: Dexamethasone
Drug: Dexmedetomidine
Drug: Hyalouridinase

First Posted Date: 2020-06-02

Last Posted Date: 2021-05-19

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT04411329

Locations: 🇪🇬
Sanaa Farag Mahmoud, Cairo, New Cairo, Egypt
🇪🇬
Ainshams hospitals, Cairo, Egypt

Rescue Quadratus Lumborum Blocks for Post-cesarean Pain

Phase 4

Withdrawn

Conditions: Morphine
Analgesics
Analgesics, Opioid
Peripheral Nervous System Agents

Interventions: Drug: Saline
Drug: Bupivacaine
Drug: Dexamethasone

First Posted Date: 2020-05-21

Last Posted Date: 2023-11-03

Lead Sponsor: The University of Texas Health Science Center, Houston

Registration Number: NCT04397458

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Dose-Escalation Study of HTX-034 Following Bunionectomy

Phase 1

Completed

Conditions: Bunions

Interventions: Drug: HTX-034
Drug: Bupivacaine HCl
Device: Luer lock applicator

First Posted Date: 2020-05-21

Last Posted Date: 2022-02-15

Lead Sponsor: Heron Therapeutics

Target Recruit Count: 73

Registration Number: NCT04398329

Locations: 🇺🇸
Endeavor Clinical Trials, LLC, San Antonio, Texas, United States
🇺🇸
Arizona Research Center, Phoenix, Arizona, United States
🇺🇸
JBR Clinical Research, Salt Lake City, Utah, United States

and more 1 locations

A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain

Phase 4

Terminated

Conditions: Pain, Postoperative

Interventions: Drug: Intrathecal morphine sulfate (ITM)
Drug: Bupivacaine hydrochloride
Drug: ropivacaine hydrochloride

First Posted Date: 2020-04-29

Last Posted Date: 2022-05-16

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 3

Registration Number: NCT04368364

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States
🇺🇸
Memorial Hermann Hospital TMC, Houston, Texas, United States