Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Stellate Ganglion Block for Major Depressive Disorder.
- Conditions
- Interventions
- First Posted Date
- 2021-01-27
- Last Posted Date
- 2024-02-09
- Lead Sponsor
- Unity Health Toronto
- Target Recruit Count
- 10
- Registration Number
- NCT04727229
- Locations
- 🇨🇦
St. Michael's Hospital, Toronto, Ontario, Canada
Evaluating the Analgesic Efficacy of Combined Individual Nerve Block in Comparison to Interscalene Nerve Block
- Conditions
- Interventions
- First Posted Date
- 2021-01-14
- Last Posted Date
- 2022-02-14
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 128
- Registration Number
- NCT04709250
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Fascia Iliaca Compartment Block Versus Anterior Quadratus Lumborum Block
- Conditions
- Interventions
- First Posted Date
- 2021-01-14
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 128
- Registration Number
- NCT04709211
- Locations
- 🇪🇬
Ain Shams University, Cairo, Abassia, Egypt
Comparison of Doses of Dexmedetomidine With Bupivacaine in Caudal Block for Duration of Analgesia in Paediatric Infraumblical Surgeries.
- Conditions
- Interventions
- First Posted Date
- 2021-01-07
- Last Posted Date
- 2021-01-07
- Lead Sponsor
- Dr. Ruth K.M. Pfau Civil Hospital, Karachi
- Target Recruit Count
- 162
- Registration Number
- NCT04700228
- Locations
- 🇵🇰
Dr. Haris Chohan, Karachi, Sindh, Pakistan
Compartment Psoas Block Efficacy and Safety
- First Posted Date
- 2020-12-01
- Last Posted Date
- 2020-12-01
- Lead Sponsor
- Bogomolets National Medical University
- Target Recruit Count
- 90
- Registration Number
- NCT04648332
- Locations
- 🇺🇦
Bogomolets NMU, Kyiv, Ukraine
REDUCE Trial: Perineural Dexamethasone on Scalp Nerve Blocks
- Conditions
- Interventions
- First Posted Date
- 2020-12-01
- Last Posted Date
- 2024-01-25
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 156
- Registration Number
- NCT04648358
- Locations
- 🇨🇳
Beijing Tiantan Hospital, Beijing, Beijing, China
Transversus Abdominis Plan Block, Ultrasound or Laparoscopic?
- Conditions
- Interventions
- First Posted Date
- 2020-11-18
- Last Posted Date
- 2021-01-28
- Lead Sponsor
- Ankara City Hospital Bilkent
- Target Recruit Count
- 60
- Registration Number
- NCT04634721
- Locations
- 🇹🇷
Ankara Şehir Hastanesi, Ankara, Çankaya, Turkey
Enhanced Recovery After Cesarean Section With Low Dose Intrathecal Morphine.
- Conditions
- Interventions
- First Posted Date
- 2020-11-05
- Last Posted Date
- 2021-03-01
- Lead Sponsor
- Minia University
- Target Recruit Count
- 60
- Registration Number
- NCT04618146
- Locations
- 🇪🇬
Minia university, Minya, Egypt
Continuous Erector Spinae Block for Post Analgesia in Pediatric Patients
- Conditions
- Interventions
- First Posted Date
- 2020-11-03
- Last Posted Date
- 2023-02-03
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT04613830
- Locations
- 🇪🇬
South Egypt Cancer instIitute, Assuit, Egypt
Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy
- Conditions
- Interventions
- First Posted Date
- 2020-10-30
- Last Posted Date
- 2021-08-30
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 110
- Registration Number
- NCT04609033
- Locations
- 🇪🇬
Assiut University Hospitals, Assiut, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.