Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Efficacy of Popliteal Block and Bupivacaine Concentration Used for Analgesia in Foot and Ankle Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-03-04
- Last Posted Date
- 2020-03-04
- Lead Sponsor
- Bozyaka Training and Research Hospital
- Target Recruit Count
- 68
- Registration Number
- NCT04294732
- Locations
- 🇹🇷
Hazal Ezgi Çifci, İzmir, Eyalet/Yerleşke, Turkey
Pre-emptive Quadratus Lumborum Block for Laparoscopic Bariatric Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-03-04
- Last Posted Date
- 2020-08-25
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 30
- Registration Number
- NCT04294329
- Locations
- 🇪🇬
Anesthesiology department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation
- Conditions
- Interventions
- First Posted Date
- 2020-03-03
- Last Posted Date
- 2024-01-29
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 30
- Registration Number
- NCT04293809
- Locations
- 🇺🇸
HD Research, Bellaire, Texas, United States
Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy
- Conditions
- Interventions
- First Posted Date
- 2020-02-17
- Last Posted Date
- 2023-08-15
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 140
- Registration Number
- NCT04272086
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
The Efficacy of Transversalis Fascia Plane Block in Pediatric Inguinal Hernia Repair
- First Posted Date
- 2020-02-17
- Last Posted Date
- 2022-11-16
- Lead Sponsor
- Ataturk University
- Target Recruit Count
- 60
- Registration Number
- NCT04272320
- Locations
- 🇹🇷
Ataturk University, Erzurum, Turkey
Ultrasound Guided Retrolaminar Block for Pediatric Inguinal Hernia
- Conditions
- Interventions
- First Posted Date
- 2020-02-12
- Last Posted Date
- 2020-05-19
- Lead Sponsor
- Mahmoud Mohammed Alseoudy
- Target Recruit Count
- 60
- Registration Number
- NCT04266132
- Locations
- 🇪🇬
Mansoura university children hospital, Mansoura, Egypt
Bupivacaine Hydrochloride for Pain Control in Cutaneous Surgery
- First Posted Date
- 2020-02-07
- Last Posted Date
- 2024-03-18
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 100
- Registration Number
- NCT04260854
- Locations
- 🇺🇸
Northwestern University Department of Dermatology, Chicago, Illinois, United States
Regional Anesthesia in Total Hip and Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2020-02-06
- Last Posted Date
- 2022-08-08
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 135
- Registration Number
- NCT04257682
Role of Opioids in Epidural Solutions
- First Posted Date
- 2020-02-05
- Last Posted Date
- 2023-04-12
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 135
- Registration Number
- NCT04251962
- Locations
- 🇮🇱
Division of Anesthesia, Pain and Critical Care, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Multimodal Pain Study in Free Flap Patients
- Conditions
- Interventions
- First Posted Date
- 2020-01-29
- Last Posted Date
- 2023-08-18
- Lead Sponsor
- University of Kansas Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT04246697
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.