Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Intrathecal Nalbuphine Versus Midazolam in Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2019-04-17
- Last Posted Date
- 2019-12-24
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 90
- Registration Number
- NCT03918187
- Locations
- 🇪🇬
Olfat Abd Elmoniem Ibrahem Amin, Zagazig, Eygpt/zagazig, Egypt
Bubiket Study: Ultrasound Guided Fascia Iliaca Nerve Block With Bupivacaine and Adjuvant Ketamine vs. Bupivacaine Alone
- First Posted Date
- 2019-04-10
- Last Posted Date
- 2021-10-11
- Lead Sponsor
- Antonios Likourezos
- Registration Number
- NCT03909594
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
Liposomal Bupivacaine After Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2019-04-09
- Last Posted Date
- 2020-07-31
- Lead Sponsor
- Wright State University
- Registration Number
- NCT03907813
- Locations
- 🇺🇸
Miami Valley Hospital, Dayton, Ohio, United States
Liposomal Bupivacaine in Vaginal Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2019-04-08
- Last Posted Date
- 2021-10-15
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 28
- Registration Number
- NCT03907033
- Locations
- 🇺🇸
Mayo Clinic in Arizona, Phoenix, Arizona, United States
Open-Label CA-008 (Vocacapsaicin) in Bunionectomy
- First Posted Date
- 2019-03-21
- Last Posted Date
- 2021-10-27
- Lead Sponsor
- Concentric Analgesics
- Target Recruit Count
- 36
- Registration Number
- NCT03885596
- Locations
- 🇺🇸
Lotus Clinical Research, LLC, Pasadena, California, United States
Effect of Adding Dexamethasone to Intrathecal Bupivacaine on Blood Sugar of Patients Undergoing Diabetic Foot Surgeries
- Conditions
- Interventions
- First Posted Date
- 2019-03-12
- Last Posted Date
- 2022-02-25
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT03871049
- Locations
- 🇪🇬
Assiut University Hospital, Assiut, Egypt
Comparing the Efficacy of Local Anesthetics in Mohs Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-03-12
- Last Posted Date
- 2020-06-16
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 105
- Registration Number
- NCT03871478
- Locations
- 🇨🇦
Mohs Surgery Clinic, Ottawa, Ontario, Canada
Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision
- First Posted Date
- 2019-03-12
- Last Posted Date
- 2021-07-14
- Lead Sponsor
- Danbury Hospital
- Target Recruit Count
- 43
- Registration Number
- NCT03870685
- Locations
- 🇺🇸
Danbury Hospital, Danbury, Connecticut, United States
Dexmedetomidine Added to Bupivacaine Versus Bupivacaine inTransincisionalU/S Guided Quadratus Lumborum Block in Open Renal Surgeries , A New Technique
- Conditions
- Interventions
- First Posted Date
- 2019-03-11
- Last Posted Date
- 2020-05-19
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 80
- Registration Number
- NCT03869047
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Post-operative Analgesic Effects of Dexamethasone Added to Bupivacaine in Transversusabdominis Plane (TAP) Block
- First Posted Date
- 2019-03-05
- Last Posted Date
- 2020-04-28
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT03863977
- Locations
- 🇪🇬
Assiut university hospitals, Assiut, Assiut Governorate, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.