Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Investigation of Corticosteroid Versus Placebo Injection in Patients With Syndesmotic Ligament Injury or High Ankle Sprain
- Conditions
- Interventions
- First Posted Date
- 2016-09-08
- Last Posted Date
- 2024-02-13
- Lead Sponsor
- Sanford Health
- Target Recruit Count
- 1
- Registration Number
- NCT02892500
- Locations
- 🇺🇸
Sanford Orthopedics and Sports Medicine, Fargo, North Dakota, United States
Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor-3
- First Posted Date
- 2016-09-02
- Last Posted Date
- 2017-05-25
- Target Recruit Count
- 40
- Registration Number
- NCT02887222
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Post- Thoracotomy Paravertebral Block
- First Posted Date
- 2016-09-01
- Last Posted Date
- 2018-12-04
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT02886429
- Locations
- 🇪🇬
Faculty of Medicine, Assiut, Egypt
Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
- Conditions
- Interventions
- First Posted Date
- 2016-09-01
- Last Posted Date
- 2022-03-24
- Lead Sponsor
- University Hospitals Cleveland Medical Center
- Target Recruit Count
- 17
- Registration Number
- NCT02886286
- Locations
- 🇺🇸
University Hospitals Case Medical Center, Cleveland, Ohio, United States
Management of Postoperative Pain With Preemptive Analgesia in Cesarean Section
- First Posted Date
- 2016-08-25
- Last Posted Date
- 2016-08-25
- Lead Sponsor
- Mark Kosanovich
- Target Recruit Count
- 120
- Registration Number
- NCT02879435
- Locations
- 🇺🇸
Mercy Hospital & Medical Center, Chicago, Illinois, United States
Scalp Block Versus Scalp Infiltration With Dexmedetomidine and Local Anesthetic for Post Craniotomy Pain
- Conditions
- Interventions
- First Posted Date
- 2016-08-15
- Last Posted Date
- 2016-08-15
- Lead Sponsor
- NAVNEH SAMAGH
- Target Recruit Count
- 150
- Registration Number
- NCT02866409
Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
- Conditions
- Interventions
- First Posted Date
- 2016-08-11
- Last Posted Date
- 2020-12-24
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 43
- Registration Number
- NCT02862912
- Locations
- 🇺🇸
New York Presbyterian Hospital, New York, New York, United States
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2016-08-11
- Last Posted Date
- 2020-10-08
- Target Recruit Count
- 63
- Registration Number
- NCT02863120
- Locations
- 🇺🇸
Texas Orthopedics, Austin, Texas, United States
Intrathecal Dexmedetomidine Versus Fentanyl With Bupivacaine in Children Undergoing Major Abdominal Cancer Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-08-10
- Last Posted Date
- 2018-04-10
- Lead Sponsor
- South Egypt Cancer Institute
- Target Recruit Count
- 60
- Registration Number
- NCT02861716
- Locations
- 🇪🇬
South Egypt Cancer Institute, Assuit, Egypt
Dual Transversus Abdominis Plane Block in Pediatric Renal Transplant: Effect on Pain Control
- Conditions
- Interventions
- First Posted Date
- 2016-08-08
- Last Posted Date
- 2019-05-07
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 44
- Registration Number
- NCT02858622
- Locations
- 🇪🇬
Faculty of medicine, Cairo University, Cairo, Egypt
Drug Development Updates
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