Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Sphenopalatine Ganglion Block for Post-Dural Puncture Headache
- Conditions
- Interventions
- First Posted Date
- 2014-07-03
- Last Posted Date
- 2017-11-08
- Lead Sponsor
- Wake Forest University Health Sciences
- Registration Number
- NCT02181205
- Locations
- 🇺🇸
Novant Health Forsyth Medical Center, Winston-Salem, North Carolina, United States
Continuous Femoral Nerve Block With a Tibial Plateau Fracture
- First Posted Date
- 2014-06-20
- Last Posted Date
- 2016-03-14
- Lead Sponsor
- University of Utah
- Target Recruit Count
- 5
- Registration Number
- NCT02168959
- Locations
- 🇺🇸
University of Utah, Salt Lake City, Utah, United States
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
- First Posted Date
- 2014-06-10
- Last Posted Date
- 2019-01-03
- Lead Sponsor
- St. Luke's-Roosevelt Hospital Center
- Target Recruit Count
- 170
- Registration Number
- NCT02159807
- Locations
- 🇺🇸
Roosevelt hospital, New York, New York, United States
Pain Control in Bariatric Patients: EXPAREL(R) vs. the On-Q(R) Pain Ball
- First Posted Date
- 2014-05-20
- Last Posted Date
- 2014-05-22
- Lead Sponsor
- Pacira Pharmaceuticals, Inc
- Target Recruit Count
- 101
- Registration Number
- NCT02142829
- Locations
- 🇺🇸
Bariatric Medical Institute of Texas, San Antonio, Texas, United States
Comparison of Bupivacaine and Exparel for Carpal Tunnel Release
- Conditions
- Interventions
- First Posted Date
- 2014-05-19
- Last Posted Date
- 2016-01-05
- Lead Sponsor
- University of Pittsburgh
- Registration Number
- NCT02141178
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair
- Conditions
- Interventions
- First Posted Date
- 2014-05-01
- Last Posted Date
- 2017-01-19
- Lead Sponsor
- Michael Moncure, MD
- Target Recruit Count
- 40
- Registration Number
- NCT02128646
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Evaluation of the Minimum Effective Concentration of Bupivacaine (EC50) in Femoral Block for Analgesia by Ultrasound After Knee Surgery
- First Posted Date
- 2014-04-28
- Last Posted Date
- 2017-08-01
- Lead Sponsor
- Ed Carlos Rey Moura
- Target Recruit Count
- 45
- Registration Number
- NCT02124005
- Locations
- 🇧🇷
Universidade Federal de São Paulo, São Paulo, SP, Brazil
Lidocaine Versus Bupivacaine in Ambulatory Continuous Block With Elastomeric Pump
- First Posted Date
- 2014-04-23
- Last Posted Date
- 2016-05-24
- Lead Sponsor
- Pontificia Universidad Catolica de Chile
- Target Recruit Count
- 70
- Registration Number
- NCT02121119
- Locations
- 🇨🇱
División de Anestesia - Facultad de Medicina Pontificia Universidad Católica, Santiago, Región Metropolitana, Chile
Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2014-04-23
- Last Posted Date
- 2020-10-20
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 165
- Registration Number
- NCT02121392
- Locations
- 🇺🇸
University of Chicago Medicine, Chicago, Illinois, United States
PAIN - Postoperative Analgesia INvestigation
- Conditions
- Interventions
- First Posted Date
- 2014-04-11
- Last Posted Date
- 2018-10-16
- Target Recruit Count
- 350
- Registration Number
- NCT02111746
- Locations
- 🇺🇸
Department of Cardiothoracic and Vascular Surgery and Memorial Hermann Heart and Vascular Institute - Texas Medical Center, Houston, Texas, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.