Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in 2012 for use with docetaxel and another HER2-targeted monoclonal antibody, trastuzumab, in the treatment of metastatic HER2-positive breast cancer. Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.
Pertuzumab is indicated for intravenous administration in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. It is also indicated in combination with trastuzumab and other chemotherapies for the neoadjuvant treatment of HER2-positive locally advanced, inflammatory, or early-stage breast cancer as part of a complete treatment regimen and as adjuvant treatment in patients with HER2-positive early-stage breast cancer at high risk of recurrence.
Pertuzumab is also indicated for subcutaneous injection - in combination with trastuzumab and hyaluronidase - in the treatment of HER2-positive breast cancers in adults.
Columbia University Irving Medical Center, New York, New York, United States
Hirslanden Klinik Aarau, Aarau, Switzerland
Kantonspital Aarau, Aarau, Switzerland
Kantonsspital Baden, Baden, Switzerland
Ev. Krankenhaus Bethesda Brustzentrum Niederrhien, Moenchengladbach, Germany
Brigham and Women's Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan, Ann Arbor, Michigan, United States
Florida Cancer Specialists - SCRI; Pharmacy, Fort Myers, Florida, United States
Weill Medical College of Cornell University; Division of Hematology & Medical Oncology, New York, New York, United States
University Of Chicago Medical Center; Section Of Hematology/Oncology, Chicago, Illinois, United States
Academ Ziekenhuis Groningen; Medical Oncology, Groningen, Netherlands
Academisch Ziekenhuis Leiden; Clinical Oncology, Leiden, Netherlands
UMC St Radboud, Nijmegen, Netherlands
Centro Oncologico Riojano Integral (CORI), La Rioja, Argentina
LKH-UNIV. KLINIKUM GRAZ; Klinische Abteilung für Onkologie, Graz, Austria
UZ Brussel, Brussel, Belgium
Ankara City Hospital, Ankara, Turkey
Washington University School of Medicine; Internal Medicine - Renal, Saint Louis, Missouri, United States
Ironwood Cancer TX & Rsch Ctrs, Chandler, Arizona, United States
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