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Hydroxocobalamin

Generic Name
Hydroxocobalamin
Brand Names
Cyanokit, Hydro-Cobex
Drug Type
Small Molecule
Chemical Formula
C62H89CoN13O15P
CAS Number
13422-51-0
Unique Ingredient Identifier
Q40X8H422O
Background

Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.

Indication

For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.

Associated Conditions
Anemia, Pernicious, Cyanide Poisoning, Vitamin B complex deficiency, Vitamin B12 Deficiency
Associated Therapies
-
Clinical Trials
Related News

Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass

Phase 2
Completed
Conditions
Vasoplegic Syndrome
Interventions
Drug: Hydroxycobalamin
First Posted Date
2023-12-07
Last Posted Date
2024-06-12
Lead Sponsor
Ain Shams University
Target Recruit Count
60
Registration Number
NCT06160219
Locations
🇪🇬

AinShams university hospitals, Cairo, Egypt

Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy

Phase 2
Not yet recruiting
Conditions
Retrognathism
Prognathism
Orthognathic Surgery
Neurosensory Disorder
Interventions
Procedure: Orthognathic Surgery
Drug: Melatonin 10 MG Oral Tablet
Drug: Centrum
Drug: Hydroxycobalamin
First Posted Date
2022-09-13
Last Posted Date
2022-09-13
Lead Sponsor
Universitat Internacional de Catalunya
Target Recruit Count
220
Registration Number
NCT05536596

Do Iron And Vitamin B12 Injections Given Together, Improve Hemoglobin In Patients On Hemodialysis?

Phase 4
Conditions
Iron Deficiency Anemia
B12 Deficiency Anemia
Interventions
Drug: Ferric carboxymaltose
Drug: Hydroxycobalamin
Drug: Placebo
First Posted Date
2020-11-13
Last Posted Date
2021-01-29
Lead Sponsor
Christian Medical College, Vellore, India
Target Recruit Count
100
Registration Number
NCT04627181
Locations
🇮🇳

Christian Medical College, Vellore, Vellore, Tamil Nadu, India

Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients

Phase 4
Completed
Conditions
Vasoplegic Syndrome
Liver Transplant; Complications
Interventions
Drug: Hydroxocobalamin
Drug: Methylene Blue
First Posted Date
2019-08-13
Last Posted Date
2024-06-24
Lead Sponsor
Mayo Clinic
Target Recruit Count
19
Registration Number
NCT04054999
Locations
🇺🇸

Mayo Clinic in Florida, Jacksonville, Florida, United States

A Trial of Vitamin B12 in Septic Shock

Phase 2
Completed
Conditions
Septic Shock
Interventions
Drug: Placebo
Drug: Hydroxocobalamin
First Posted Date
2018-12-20
Last Posted Date
2024-11-27
Lead Sponsor
Medical College of Wisconsin
Target Recruit Count
20
Registration Number
NCT03783091
Locations
🇺🇸

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Vitamin B12a Vasoplegic Syndrome

Phase 2
Terminated
Conditions
Vasoplegic Syndrome
Interventions
Drug: Hydroxocobalamin
Drug: Placebos
Procedure: Cardiopulmonary Bypass
First Posted Date
2018-11-08
Last Posted Date
2023-05-10
Lead Sponsor
Mayo Clinic
Target Recruit Count
8
Registration Number
NCT03735316
Locations
🇺🇸

Mayo Clinic Saint Mary's Hospital, Rochester, Minnesota, United States

Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery

Phase 2
Withdrawn
Conditions
Hypotension
Coronary Artery Disease
Cardiac Valve Disease
Vasoplegia
Interventions
Drug: Hydroxocobalamin
Drug: Methylene Blue
Drug: Normal saline
First Posted Date
2018-02-27
Last Posted Date
2020-03-02
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Registration Number
NCT03446599
Locations
🇺🇸

Dartmouth-Hitchcock, Lebanon, New Hampshire, United States

Vitamin Deficiencies and Suppletion in Morbid Obesity

Phase 4
Completed
Conditions
Vitamin B12 Deficiency
Interventions
Drug: FitForMe vitamin B12
Drug: Hydroxocobalamin
First Posted Date
2014-10-21
Last Posted Date
2020-06-11
Lead Sponsor
Rijnstate Hospital
Target Recruit Count
50
Registration Number
NCT02270749
Locations
🇳🇱

Rijnstate hospital, Arnhem, Netherlands

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