Riboflavin

Generic Name: Riboflavin

Brand Names: Alertonic, Concept Ob, Irospan 24/6 Kit, Mvc-fluoride, Natafort, Pregvit, Tandem Plus, Vitafol-one

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₀N_₄O_₆

CAS Number: 83-88-5

Unique Ingredient Identifier: TLM2976OFR

Background: Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Indication: For the treatment of ariboflavinosis (vitamin B2 deficiency).

Associated Conditions: Ariboflavinosis, Beriberi, Constipation, Functional Gastrointestinal Disorders (FGID), Joint Pain, Metabolic cardiomyopathy, Migraine, Myalgia, Neuropathic Pain, Peripheral neuritis, Peripheral paralysis, Vitamin B complex deficiency, Vitamin B1 deficiency, Vitamin Deficiency, Wernicke's encephalopathy

Associated Therapies: Dietary and Nutritional Therapies, Nutritional supplementation, Vitamin supplementation, Dietary supplementation

Clinical Trials

Safety Study of the VEGA UV-A System to Treat Keratoconus

Phase 3

Terminated

Conditions: Keratoconus

Interventions: Drug: Riboflavin
Device: The VEGA UV-A Illumination System

First Posted Date: 2010-08-27

Last Posted Date: 2022-07-12

Lead Sponsor: Topcon Medical Systems, Inc.

Target Recruit Count: 127

Registration Number: NCT01190306

Locations: 🇺🇸
Woolfson Eye Institute, Atlanta, Georgia, United States
🇺🇸
Barnet Dulaney Perkins Eye Center, Phoenix, Arizona, United States
🇺🇸
Minnesota Eye Consultants, Bloomington, Minnesota, United States

and more 6 locations

Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia

Phase 2

Completed

Conditions: Keratoconus
Post-Refractive Ectasia

Interventions: Drug: Riboflavin
Device: UVX light

First Posted Date: 2010-06-14

Last Posted Date: 2018-06-06

Lead Sponsor: Price Vision Group

Target Recruit Count: 510

Registration Number: NCT01143389

Locations: 🇺🇸
Price Vision Group, Indianapolis, Indiana, United States

Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia

Phase 3

Active, not recruiting

Conditions: Keratoconus
Corneal Ectasia

Interventions: Drug: Riboflavin

First Posted Date: 2010-04-28

Last Posted Date: 2023-02-08

Lead Sponsor: Cornea and Laser Eye Institute

Target Recruit Count: 160

Registration Number: NCT01112072

Locations: 🇺🇸
Cornea and Laser Eye Institute, Teaneck, New Jersey, United States

Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs

Phase 2

Conditions: Keratoconus
Ectasia

Interventions: Drug: Riboflavin

First Posted Date: 2010-03-05

Last Posted Date: 2018-10-02

Lead Sponsor: Yaron S. Rabinowitz M.D.

Target Recruit Count: 600

Registration Number: NCT01081561

Locations: 🇺🇸
Cornea Eye Institute, 50 North La Cienaga Blvd, #340, Beverly Hills, California, United States

Cross Linking for Treatment of Corneal Infection

Not Applicable

Terminated

Conditions: Infectious Keratitis

Interventions: Drug: riboflavin
Device: UVX Light

First Posted Date: 2009-06-03

Last Posted Date: 2017-11-22

Lead Sponsor: Price Vision Group

Target Recruit Count: 30

Registration Number: NCT00912509

Locations: 🇺🇸
Price Vision Group, Indianapolis, Indiana, United States

Corneal Crosslinking in Keratoconus and Corneal Ectasia

Phase 2

Withdrawn

Conditions: Progressive Keratoconus
Corneal Ectasia

Interventions: Drug: Placebo
Drug: Riboflavin

First Posted Date: 2008-05-19

Last Posted Date: 2017-04-20

Lead Sponsor: Ohio State University

Registration Number: NCT00679666

Locations: 🇺🇸
OSU Havener Eye Institute, Dublin, Ohio, United States
🇺🇸
The Ohio State University Medical Center, Columbus, Ohio, United States

A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs

Not Applicable

Withdrawn

Conditions: HIV Infections

First Posted Date: 2002-05-15

Last Posted Date: 2015-06-04

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Registration Number: NCT00037063

Locations: 🇺🇸
Univ of Colorado Health Sciences Ctr, Denver, Colorado, United States
🇺🇸
Case Western Reserve Univ, Cleveland, Ohio, United States
🇺🇸
Univ of Pennsylvania, Philadelphia, Philadelphia, Pennsylvania, United States

and more 1 locations

Vitamin B Therapy for Hyperlactatemia

Not Applicable

Completed

Conditions: HIV Infections

First Posted Date: 2002-02-22

Last Posted Date: 2011-02-28

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 225

Registration Number: NCT00031057

Locations: 🇺🇸
Case Western Reserve Univ, Cleveland, Ohio, United States
🇺🇸
Univ of North Carolina, Chapel Hill, North Carolina, United States
🇺🇸
Beth Israel Med Ctr, New York, New York, United States

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