DeepMed Research

Fluorometholone

Generic Name: Fluorometholone

Brand Names: FML, FML Forte Liquifilm, FML-S, Flarex, Fluor-OP

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₄

CAS Number: 426-13-1

Unique Ingredient Identifier: SV0CSG527L

Background: A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)

Indication: For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.

Associated Conditions: Allergic Conjunctivitis (AC), Anterior chamber inflammation, Inflammation, Keratitis, Ocular Inflammation, Ocular bacterial infections

Clinical Trials

Once-daily Fluorometholone Vs Twice-daily Cyclosporine in Dry Eye Disease

Phase 4

Completed

Conditions: Dry Eye Disease (DED)

Interventions: Drug: Fluorometholone 0.1% ophthalmic solution
Drug: Cyclosporine 0.05% eye drops

First Posted Date: 2025-03-14

Last Posted Date: 2025-03-14

Lead Sponsor: Korea University Anam Hospital

Target Recruit Count: 32

Registration Number: NCT06876116

Locations: 🇰🇷
Korea University Anam Hospital, Seoul, Korea, Republic of

The OPTIMISE Study

Phase 4

Not yet recruiting

Conditions: Intraocular Pressure
Pseudophakic Bullous Keratopathy
Fuchs' Endothelial Dystrophy

Interventions: Drug: Dexamethasone 0.1% ophthalmic suspension
Other: Stop steroids
Drug: Fluorometholone 0.1% Oph Susp

First Posted Date: 2023-02-08

Last Posted Date: 2023-02-10

Lead Sponsor: Maastricht University Medical Center

Target Recruit Count: 342

Registration Number: NCT05716945

Comparison of the Postoperative Use of Dextenza vs a Standard Regimen After PRK

Phase 4

Not yet recruiting

Conditions: Steroid Ophthalmic Insert

Interventions: Drug: Dextenza 0.4Mg Ophthalmic Insert
Drug: Topical Fluorometholone

First Posted Date: 2022-10-20

Last Posted Date: 2022-10-20

Lead Sponsor: Navy Medical Center San Diego

Target Recruit Count: 60

Registration Number: NCT05587231

Effect of Various Treatment Modalities on Dendritic Vial Ulcer

Conditions: Corneal Ulcer

Interventions: Drug: Acyclovir
Drug: Tobramycin
Drug: Sodium Hyaluronate
Drug: Fluorometholone

First Posted Date: 2022-04-06

Last Posted Date: 2022-04-06

Lead Sponsor: Sohag University

Target Recruit Count: 40

Registration Number: NCT05313828

Locations: 🇪🇬
Sohag University, Sohag, Egypt

Treatment of Corneal Infiltrates Secondary to Epidemic Keratoconjunctivitis

Phase 4

Completed

Conditions: Adenoviral Keratoconjunctivitis

Interventions: Drug: Cyclosporine A eye drops 0.5%
Drug: FLUCON®

First Posted Date: 2020-05-06

Last Posted Date: 2020-05-07

Lead Sponsor: Military Hospital of Tunis

Target Recruit Count: 51

Registration Number: NCT04376970

Locations: 🇹🇳
Military Hospital of Tunis, Tunis, Illinois, Tunisia

FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial

Phase 3

Completed

Conditions: Trachomatous Trichiasis (TT)
Trichiasis
Eye Diseases
Eyelid Diseases
Trachomatous

Interventions: Drug: Fluorometholone 0.1% Oph Susp
Drug: Artificial Tears

First Posted Date: 2019-11-04

Last Posted Date: 2025-02-27

Lead Sponsor: Massachusetts Eye and Ear Infirmary

Target Recruit Count: 2410

Registration Number: NCT04149210

Locations: 🇪🇹
Oromia Health Bureau, Addis Ababa, Ethiopia

Ocular Micro-vascular Research Base on Functional Slip Lamp Biomicroscopy

Phase 4

Conditions: Microvessels
Inflammation
Dry Eye Syndromes

Interventions: Drug: Fluorometholone
Device: Functional Slit-Lamp Biomicroscopy

First Posted Date: 2018-11-20

Last Posted Date: 2018-11-20

Lead Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University

Target Recruit Count: 20

Registration Number: NCT03747614

Locations: 🇨🇳
Wan Chen, Guangzhou, Guangdong, China

Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery

Phase 4

Completed

Conditions: Intraocular Pressure

Interventions: Drug: 0.1 % Dexamethasone
Drug: 0.1% Fluorometholone
Drug: 1% Rimexolone

First Posted Date: 2016-06-29

Last Posted Date: 2016-06-29

Lead Sponsor: Cairo University

Target Recruit Count: 40

Registration Number: NCT02816905

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)

Phase 3

Completed

Conditions: Dry Eye

Interventions: Drug: FML 0.1% eyedrops
Drug: Liquifilm artificial tears eyedrops

First Posted Date: 2014-01-31

Last Posted Date: 2015-01-08

Lead Sponsor: Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA

Target Recruit Count: 41

Registration Number: NCT02051023

Locations: 🇪🇸
IOBA (Instituto de Oftalmobiología Aplicada), University of Valladolid, Valladolid, Spain
🇪🇸
IOBA, Valladolid, Spain

The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements

Phase 2

Conditions: Corneal Opacity

Interventions: Drug: Fluorometholone 1% topical ocular steroid
Drug: Mitomycin-C

First Posted Date: 2014-01-09

Last Posted Date: 2022-04-15

Lead Sponsor: United States Naval Medical Center, San Diego

Target Recruit Count: 300

Registration Number: NCT02030990

Locations: 🇺🇸
Navy Warfighter Refractive Surgery Center, San Diego, California, United States

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