Cefazolin
- Generic Name
- Cefazolin
- Drug Type
- Small Molecule
- Chemical Formula
- C14H14N8O4S3
- CAS Number
- 25953-19-9
- Unique Ingredient Identifier
- IHS69L0Y4T
- Background
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
- Indication
Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
- Associated Conditions
- Bacterial Septicemia caused by susceptible Bacterial Infections, Biliary tract infection bacterial caused by susceptible Bacterial Infections, Bone and Joint Infections caused by susceptible Bacterial Infections, Catheter-related Bloodstream Infection (CRBSI) NOS, Community Acquired Pneumonia (CAP), Endocarditis caused by susceptible Bacterial Infections, Genital infection caused by susceptible Bacterial Infections, Osteoarticular Infections, Postoperative Infections, Respiratory Tract Infection Bacterial caused by susceptible Bacterial Infections, Skin and Soft Tissue Infections (SSTIs), Skin and Subcutaneous Tissue Infection caused by susceptible Bacterial Infections, Susceptible infections, Urinary Tract Infection caused by susceptible Bacterial Infections, Perioperative infection, Susceptible Bacterial Infections
- Associated Therapies
- Antibiotic pre-surgical prophylaxis
The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients
- Conditions
- Antibiotic ProphylaxisWound InfectionGroin Hernia
- Interventions
- First Posted Date
- 2024-08-28
- Last Posted Date
- 2024-08-28
- Lead Sponsor
- University of Aleppo
- Target Recruit Count
- 200
- Registration Number
- NCT06576154
- Locations
- 🇸🇾
Aleppo University Hospital, Aleppo, Syrian Arab Republic
Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial
- Conditions
- Infection, Surgical Site
- Interventions
- First Posted Date
- 2024-08-23
- Last Posted Date
- 2025-03-12
- Lead Sponsor
- Hamilton Health Sciences Corporation
- Target Recruit Count
- 38000
- Registration Number
- NCT06567808
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
- Conditions
- Infection Prosthesis Hip and KneeInfection, Prosthesis RelatedJoint InfectionInfection, Surgical SiteInfection ProSurgical Site Infection
- Interventions
- First Posted Date
- 2024-05-07
- Last Posted Date
- 2024-05-07
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 751
- Registration Number
- NCT06402591
- Locations
- 🇳🇱
Radboudumc, Nijmegen, Gelderland, Netherlands
Prophylactic Antibiotics Duration Towards Healing and Risk of Infection in Permanent Pacemaker (PPM) Installation
- First Posted Date
- 2024-04-09
- Last Posted Date
- 2024-04-09
- Lead Sponsor
- University of Brawijaya
- Target Recruit Count
- 100
- Registration Number
- NCT06355115
- Locations
- 🇮🇩
RSUD Dr. Saiful Anwar, Malang, Jawa Timur, Indonesia
Antibiotic Tumescent For Chronic Wounds
- First Posted Date
- 2024-03-25
- Last Posted Date
- 2025-04-24
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 60
- Registration Number
- NCT06327113
- Locations
- 🇺🇸
University of California, Los Angeles, Los Angeles, California, United States
Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial
- Conditions
- Periprosthetic Joint Infection
- Interventions
- First Posted Date
- 2024-01-05
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- Chang Gung Memorial Hospital
- Target Recruit Count
- 184
- Registration Number
- NCT06189885
- Locations
- 🇨🇳
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
Antibiotic Prophylaxis in Pediatric Open Fractures
- First Posted Date
- 2023-09-28
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- St. Louis University
- Target Recruit Count
- 800
- Registration Number
- NCT06055712
- Locations
- 🇺🇸
Saint Louis University, Saint Louis, Missouri, United States
Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome
- Conditions
- Cesarean Section ComplicationsMicrobial ColonizationAntibiotic Side Effect
- Interventions
- First Posted Date
- 2023-09-11
- Last Posted Date
- 2023-09-13
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 33
- Registration Number
- NCT06030713
- Locations
- 🇳🇱
University Medical Center Groningen, Groningen, Netherlands
Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis
- First Posted Date
- 2023-08-22
- Last Posted Date
- 2024-12-20
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 104
- Registration Number
- NCT06005168
- Locations
- 🇺🇸
University of Michigan Hospital, Ann Arbor, Michigan, United States
Antibiotics for Prevention of Infection Following Orthognathic Surgery
- Conditions
- Orthognathic Surgical Site Infection
- Interventions
- First Posted Date
- 2023-05-10
- Last Posted Date
- 2024-05-14
- Lead Sponsor
- Abdul El-Rabbany
- Target Recruit Count
- 400
- Registration Number
- NCT05852158
- Locations
- 🇨🇦
Victoria General Hospital, Halifax, Nova Scotia, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.