Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Sunitinib is indicated for the following conditions:
Oncology Hematology Care, Cincinnati, Ohio, United States
Florida Hospital Cancer Insitute, Orlando, Florida, United States
Northeast Georgia Medical Center, Gainesville, Georgia, United States
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Grant Medical Center, Columbus, Ohio, United States
The Mark H Zangmeister Center, Columbus, Ohio, United States
Hematology Oncology Associates of Illinois - Skokie, Skokie, Illinois, United States
University of Kansas Hospital, Kansas City, Kansas, United States
City of Hope, Duarte, California, United States
Emory University, Atlanta, Georgia, United States
Pfizer Investigational Site, Swansea, United Kingdom
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
MD Anderson, University of Texas, Houston, Texas, United States
Duke University Medical Center, Durham, North Carolina, United States
Pfizer Investigational Site, Minoh/Osaka, Japan
Hospital Parc Taulí, Sabadell, Barcelona, Spain
Hospital lozano Blesa, Zaragoza, Spain
Hospital CLINIC, Barcelona, Spain
Pfizer Investigational Site, Osaka, Japan
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.