Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Sunitinib is indicated for the following conditions:
Austin Health (Ludwig Institute Oncology Unit), Heidelberg, Victoria, Australia
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States
Kantonsspital - St. Gallen, St. Gallen, Switzerland
Skagit Valley Hospital, Mount Vernon, Washington, United States
Olympic Medical Center, Port Angeles, Washington, United States
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States
Mayo Clinic Cancer Research Consortium, Rochester, Minnesota, United States
Centre Paul Papin - 2 rue Moll, Angers, France
Département Endocrinolo-Diabéto-Nutrition - CHU d'Angers - 4 rue de Larray, Angers, France
Service d'Oncologie Médicale et de Radiothérapie - Hôpital Saint André - 1 rue Jean Burguet, Bordeaux, France
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States
Ohio State University Medical Center, Columbus, Ohio, United States
H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States
UT MD Anderson Cancer Center, Houston, Texas, United States
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