Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
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Intravenous Dexamethasone to Increase the Analgesic Duration of Interscalene Block
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2018-09-13
- Lead Sponsor
- Maisonneuve-Rosemont Hospital
- Target Recruit Count
- 75
- Registration Number
- NCT02412657
- Locations
- 🇨🇦
Hopital Pierre-Boucher, Longueuil, Quebec, Canada
🇨🇦Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
🇨🇦Hopital Hotel-Dieu de Sorel, Sorel, Quebec, Canada
Ixazomib, Cyclophosphamide and Dexamethasone for Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2022-07-25
- Lead Sponsor
- John L. Reagan
- Target Recruit Count
- 12
- Registration Number
- NCT02412228
- Locations
- 🇺🇸
Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, United States
🇺🇸The Miriam Hospital, Providence, Rhode Island, United States
🇺🇸Rhode Island Hospital, Providence, Rhode Island, United States
Ixazomib in Combination With Thalidomide - Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2015-04-08
- Last Posted Date
- 2019-12-13
- Lead Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
- Target Recruit Count
- 90
- Registration Number
- NCT02410694
- Locations
- 🇦🇹
UK Innsbruck, Universitätsklinik für Innere Medizin, Klinische Abteilung für Hämatologie und Onkologie, Innsbruck, Tirol, Austria
🇨🇿Faculty Hospital Brno and Faculty of Medicine MU Brno 2nd Internal Clinic, Brno, Czechia
🇨🇿Fakultní nemocnice Ostrava, Ostrava-Poruba, Czechia
Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for Head-neck and Lung Cancer
- Conditions
- Head and Neck CancerNon-small Cell Lung Cancer
- Interventions
- Drug: PlaceboDrug: Dexamethasone
- First Posted Date
- 2015-04-07
- Last Posted Date
- 2019-05-14
- Lead Sponsor
- University of Arizona
- Target Recruit Count
- 79
- Registration Number
- NCT02410382
- Locations
- 🇺🇸
University of Arizona, Tucson, Arizona, United States
Effect of Slow Release Hydrocortisone on Fed & Fasting Volunteers; Immediate Release on Fasting Only
- First Posted Date
- 2015-04-03
- Last Posted Date
- 2022-05-04
- Lead Sponsor
- Diurnal Limited
- Target Recruit Count
- 18
- Registration Number
- NCT02408068
Pomalidomide in Relapsed and Refractory Multiple Myeloma (RRMM)
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2015-04-02
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- University of Leeds
- Target Recruit Count
- 124
- Registration Number
- NCT02406222
- Locations
- 🇬🇧
Beatson Oncology Centre, Glasgow, United Kingdom
🇬🇧New Cross Hospital, Wolverhampton, United Kingdom
🇬🇧Royal Sussex County Hospital, Brighton, United Kingdom
Trial Studying Maintenance Treatment With Lenalidomide and Dexamethasone Versus Lenalidomide, Dexamethasone and MLN9708 After Autologous Hematopoietic Stem Cell Transplantation in Patients With Newly-diagnosed Symptomatic Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2015-04-02
- Last Posted Date
- 2017-11-30
- Lead Sponsor
- PETHEMA Foundation
- Target Recruit Count
- 316
- Registration Number
- NCT02406144
- Locations
- 🇪🇸
Hospital de La Santa Creu I Sant Pau, Barcelona, Spain
🇪🇸Hospital Universitari Mútua de Terrasa, Barcelona, Spain
🇪🇸Hospital Vall D'Hebron, Barcelona, Spain
Safety and Efficacy of Entospletinib With Vincristine and Dexamethasone in Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
- Conditions
- Acute Lymphoblastic Leukemia
- Interventions
- First Posted Date
- 2015-03-31
- Last Posted Date
- 2020-01-02
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT02404220
- Locations
- 🇺🇸
Hackensack University Medical Center, Hackensack, New Jersey, United States
🇺🇸UCLA, Los Angeles, California, United States
🇩🇪Medizinische Klinik und Poliklinik I, Wurzburg, Germany
Pre-Emptive Analgesia in Ano-Rectal Surgery
- Conditions
- HemorrhoidsFissure in AnoRectal FistulaAnal Condyloma
- Interventions
- First Posted Date
- 2015-03-30
- Last Posted Date
- 2018-01-16
- Lead Sponsor
- University of Vermont
- Target Recruit Count
- 90
- Registration Number
- NCT02402543
- Locations
- 🇺🇸
University of Vermont Medical Center, Burlington, Vermont, United States
🇺🇸University of Vermont Medical Center Fanny Allen Campus, Colchester, Vermont, United States
A Open-label Study of Ultra-High Dose Dexamethasone for Relapsed Multiple Myeloma
- First Posted Date
- 2015-03-30
- Last Posted Date
- 2017-02-15
- Lead Sponsor
- Boston Medical Center
- Registration Number
- NCT02402725
- Locations
- 🇺🇸
Boston Medical Center, Boston, Massachusetts, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.