Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Improving White Blood Cell Collection From Healthy Donors

Phase 4

Recruiting

Conditions: Allogeneic Granulocyte Donation

Interventions: Drug: Filgrastim
Drug: Dexamethasone

First Posted Date: 2012-03-14

Last Posted Date: 2024-12-19

Lead Sponsor: National Institutes of Health Clinical Center (CC)

Target Recruit Count: 1000

Registration Number: NCT01553214

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Study of the Combination of Panobinostat & Carfilzomib in Patients With Relapsed &/or Refractory Multiple Myeloma

Phase 1

Completed

Conditions: Multiple Myeloma

Interventions: Drug: Panobinostat
Drug: Carfilzomib
Drug: Dexamethasone

First Posted Date: 2012-03-09

Last Posted Date: 2019-01-16

Lead Sponsor: Emory University

Target Recruit Count: 32

Registration Number: NCT01549431

Locations: 🇺🇸
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
🇺🇸
Emory University Winship Cancer Institute, Atlanta, Georgia, United States
🇺🇸
University of Chicago, Chicago, Illinois, United States

Tandem Auto Transplantation in Myeloma Patients With <12 Months of Prior Treatment

Phase 2

Terminated

Conditions: Multiple Myeloma

Interventions: Drug: Dexamethasone
Procedure: Tandem autologous stem cell transplant
Drug: Cisplatin
Drug: Doxorubicin
Drug: Cyclophosphamide
Drug: Etoposide
Drug: Bortezomib
Drug: Thalidomide
Drug: Melphalan

First Posted Date: 2012-03-08

Last Posted Date: 2017-06-14

Lead Sponsor: University of Iowa

Target Recruit Count: 19

Registration Number: NCT01548573

Locations: 🇺🇸
University of Iowa Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Prevention Post Operative Nausea Vomiting in Ambulatory Gynecologic Laparoscopy

Phase 2

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Drug: Ondansetron
Drug: Dexamethasone
Drug: Dimenhydrinate

First Posted Date: 2012-03-05

Last Posted Date: 2012-07-31

Lead Sponsor: Prince of Songkla University

Target Recruit Count: 340

Registration Number: NCT01543945

Locations: 🇹🇭
Anesthesiology Department, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand

Pomalidomide, Dexamethasone and Pegylated Liposomal Doxorubicin for Relapsed/Refractory Multiple Myeloma

Phase 1

Conditions: Multiple Myeloma

Interventions: Drug: Pomalidomide
Drug: Pegylated Liposomal Doxorubicin (PLD)
Drug: Dexamethasone

First Posted Date: 2012-02-29

Last Posted Date: 2016-03-10

Lead Sponsor: Oncotherapeutics

Target Recruit Count: 70

Registration Number: NCT01541332

Locations: 🇺🇸
Mission Hope Cancer Center, Santa Maria, California, United States
🇺🇸
Pacific Cancer Care, Salinas, California, United States
🇺🇸
Roy and Patricia Disney Family Cancer Center, Burbank, California, United States

and more 5 locations