Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery
- First Posted Date
- 2009-11-04
- Last Posted Date
- 2016-12-30
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 123
- Registration Number
- NCT01007500
- Locations
- 🇰🇷
Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
- Conditions
- Leukemia
- First Posted Date
- 2009-11-01
- Last Posted Date
- 2014-01-10
- Target Recruit Count
- 180
- Registration Number
- NCT01005758
Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
- First Posted Date
- 2009-11-01
- Last Posted Date
- 2023-01-06
- Lead Sponsor
- OHSU Knight Cancer Institute
- Target Recruit Count
- 11
- Registration Number
- NCT01005914
- Locations
- 🇺🇸
OHSU Knight Cancer Institute, Portland, Oregon, United States
First-line Dasatinib Plus Conventional Chemotherapy in Adults With Newly Diagnosed Ph-Positive ALL
- Conditions
- Acute Lymphoblastic Leukemia
- Interventions
- First Posted Date
- 2009-10-30
- Last Posted Date
- 2015-05-29
- Lead Sponsor
- The Catholic University of Korea
- Target Recruit Count
- 51
- Registration Number
- NCT01004497
- Locations
- 🇰🇷
Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, Korea, Republic of
🇰🇷Yonsei University Severance Hospital, Seoul, Korea, Republic of
🇰🇷Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, Korea, Republic of
Assessment of Efficacy and Safety of Perifosine, Bortezomib and Dexamethasone in Multiple Myeloma Patients
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2009-10-27
- Last Posted Date
- 2018-02-09
- Lead Sponsor
- AEterna Zentaris
- Target Recruit Count
- 135
- Registration Number
- NCT01002248
- Locations
- 🇺🇸
Dana Farber Cancer Institute, Boston, Massachusetts, United States
🇮🇪Keryx / AOI Pharmaceuticals Investigative Site, Dublin 7, Ireland
Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome
- Conditions
- Polycystic Ovary Syndrome
- Interventions
- Radiation: 3-D UltrasoundDrug: recombinant human chorionic gonadotropinDrug: Recombinant human follicle stimulating hormoneDrug: AdrenocorticotropinDrug: DexamethasoneDrug: Glucose
- First Posted Date
- 2009-10-06
- Last Posted Date
- 2018-06-04
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 41
- Registration Number
- NCT00989781
- Locations
- 🇺🇸
UCSD Medical Center, San Diego, California, United States
Dexamethasone Tolerability in the Treatment of Acute Asthma in Children
- First Posted Date
- 2009-09-09
- Last Posted Date
- 2015-08-26
- Lead Sponsor
- IWK Health Centre
- Target Recruit Count
- 430
- Registration Number
- NCT00973687
- Locations
- 🇨🇦
IWK Health Centre, Halifax, Nova Scotia, Canada
Effect of Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Relapsed After 1-3 Prior Lines of Therapy
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2009-09-09
- Last Posted Date
- 2014-08-05
- Lead Sponsor
- University of Athens
- Target Recruit Count
- 17
- Registration Number
- NCT00972959
- Locations
- 🇬🇷
Department of Clinical Therapeutics, University of Athens School of Medicine, "Alexandra" General Hospital, Athens, Greece
🇬🇷Department of Hematology, "Theagenion" Cancer Center, Thessaloniki, Greece
🇬🇷Department of Hematology & Medical Research, 251 General Air Force Hospital, Athens, Greece
RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia
- Conditions
- Acute Lymphocytic LeukemiaLeukemia
- Interventions
- First Posted Date
- 2009-08-28
- Last Posted Date
- 2019-02-27
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 24
- Registration Number
- NCT00968253
- Locations
- 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
- Conditions
- Leukemia
- Interventions
- First Posted Date
- 2009-08-27
- Last Posted Date
- 2013-08-12
- Lead Sponsor
- Children's Cancer and Leukaemia Group
- Target Recruit Count
- 470
- Registration Number
- NCT00967057
- Locations
- 🇬🇧
Great Ormond Street Hospital for Children, London, England, United Kingdom
🇬🇧Christie Hospital, Manchester, England, United Kingdom
🇦🇺Women's and Children's Hospital, North Adelaide, South Australia, Australia
Drug Development Updates
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