Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Hormone Therapy and Radiation Therapy or Hormone Therapy and Radiation Therapy Followed by Docetaxel and Prednisone in Treating Patients With Localized Prostate Cancer
- Conditions
- Interventions
- First Posted Date
- 2006-02-07
- Last Posted Date
- 2022-06-21
- Lead Sponsor
- Radiation Therapy Oncology Group
- Target Recruit Count
- 612
- Registration Number
- NCT00288080
- Locations
- 🇺🇸
DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis, Maryland, United States
🇺🇸St. Agnes Hospital Cancer Center, Baltimore, Maryland, United States
🇺🇸Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland, Ohio, United States
Treatment of Mantle Cell Lymphoma at Diagnosis for Patients Under 65 Years
- First Posted Date
- 2006-02-02
- Last Posted Date
- 2009-02-12
- Lead Sponsor
- French Innovative Leukemia Organisation
- Target Recruit Count
- 39
- Registration Number
- NCT00285389
- Locations
- 🇫🇷
Regional university hospital, Rennes, France
🇫🇷REgional Hospital, Tours, France
Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell Lymphoma
- Conditions
- First Posted Date
- 2006-01-31
- Last Posted Date
- 2013-02-28
- Lead Sponsor
- University Hospital, Limoges
- Target Recruit Count
- 40
- Registration Number
- NCT00283985
- Locations
- 🇫🇷
Service d'Hématologie, Evry, France
🇫🇷Département Maladies du Sang, Angers, France
🇫🇷CH Annecy, Annecy, France
Combination Chemotherapy, Total-Body Irradiation, and Alemtuzumab in Treating Patients Undergoing an Autologous Stem Cell Transplant for Stage I, Stage II, Stage III, or Stage IV Chronic Lymphocytic Leukemia
- Conditions
- First Posted Date
- 2006-01-13
- Last Posted Date
- 2016-09-26
- Lead Sponsor
- German CLL Study Group
- Target Recruit Count
- 30
- Registration Number
- NCT00276809
- Locations
- 🇩🇪
Medizinische Hochschule Hannover, Hannover, Germany
🇩🇪Universitatsklinikum Heidelberg, Heidelberg, Germany
🇩🇪University Hospital Schleswig-Holstein - Kiel Campus, Kiel, Germany
Induction Therapy Study in Live Donor Kidney Transplant Recipients With a Positive Crossmatch
- First Posted Date
- 2006-01-12
- Last Posted Date
- 2018-01-18
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 56
- Registration Number
- NCT00275509
- Locations
- 🇺🇸
The Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States
Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma
- Conditions
- First Posted Date
- 2006-01-11
- Last Posted Date
- 2013-07-10
- Lead Sponsor
- Children's Cancer and Leukaemia Group
- Target Recruit Count
- 600
- Registration Number
- NCT00275106
- Locations
- 🇬🇧
Addenbrooke's Hospital, Cambridge, England, United Kingdom
🇬🇧Royal Manchester Children's Hospital, Manchester, England, United Kingdom
🇩🇪Kinderklinik, Giessen, Germany
Cyclophosphamide and Total Body Irradiation in Treating Patients Who Are Undergoing an Autologous Peripheral Stem Cell Transplant For Chronic Lymphocytic Leukemia
- Conditions
- Interventions
- First Posted Date
- 2006-01-11
- Last Posted Date
- 2018-05-11
- Lead Sponsor
- German CLL Study Group
- Target Recruit Count
- 169
- Registration Number
- NCT00275015
- Locations
- 🇩🇪
Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin, Germany
🇩🇪Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch, Berlin, Germany
🇩🇪Internistische Praxis - Trier, Trier, Germany
Arsenic Trioxide, Ascorbic Acid, Dexamethasone, and Thalidomide in Myelofibrosis/Myeloproliferative Disorder
- First Posted Date
- 2006-01-11
- Last Posted Date
- 2020-07-27
- Lead Sponsor
- Case Comprehensive Cancer Center
- Target Recruit Count
- 15
- Registration Number
- NCT00274820
- Locations
- 🇺🇸
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
🇺🇸Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection
- Conditions
- First Posted Date
- 2006-01-09
- Last Posted Date
- 2016-06-29
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 2000
- Registration Number
- NCT00273377
- Locations
- 🇮🇪
Mater Misericordiae Hospital, Dublin, Ireland
🇺🇸Outcomes Research Institute, Louisville, Kentucky, United States
🇺🇸Cleveland Clinic, Cleveland, Ohio, United States
Higher Frequency Zoledronic Acid in the Treatment of Multiple Myeloma
- Conditions
- Interventions
- First Posted Date
- 2005-12-08
- Last Posted Date
- 2011-07-21
- Lead Sponsor
- Gleneagles Hospital
- Target Recruit Count
- 56
- Registration Number
- NCT00263484
- Locations
- 🇮🇳
Christian Medical College, Vellore, Tamil Nadu, India
🇮🇳Tata Memorial Hospital, Mumbai, India
🇰🇷Chonnam National University Hwasun Hospital, Kwangju, Korea, Republic of
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.