Dexamethasone

Generic Name
Dexamethasone
Brand Names
Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
Drug Type
Small Molecule
Chemical Formula
C22H29FO5
CAS Number
50-02-2
Unique Ingredient Identifier
7S5I7G3JQL
Background

Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
...

Indication

Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, an...

Associated Conditions
Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
Associated Therapies
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Dexamethasone Followed by Denileukin Diftitox in Treating Patients With Persistent or Recurrent T-Cell Lymphoma

First Posted Date
2004-03-25
Last Posted Date
2013-05-30
Lead Sponsor
Ligand Pharmaceuticals
Registration Number
NCT00006345
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Veterans Affairs Medical Center - Miami, Miami, Florida, United States

๐Ÿ‡บ๐Ÿ‡ธ

Washington University School of Medicine, Saint Louis, Missouri, United States

๐Ÿ‡บ๐Ÿ‡ธ

Rush Cancer Institute, Chicago, Illinois, United States

and more 8 locations

S9922 Combination Chemo Plus Filgrastim With or Without Thalidomide in Refractory Multiple Myeloma

First Posted Date
2004-03-16
Last Posted Date
2015-03-06
Lead Sponsor
SWOG Cancer Research Network
Target Recruit Count
19
Registration Number
NCT00005834
Locations
๐Ÿ‡บ๐Ÿ‡ธ

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

๐Ÿ‡บ๐Ÿ‡ธ

Veterans Affairs Outpatient Clinic - Martinez, Martinez, California, United States

and more 90 locations

Isotretinoin Plus Dexamethasone in Treating Patients With Multiple Myeloma

First Posted Date
2004-03-11
Last Posted Date
2013-07-10
Lead Sponsor
Fox Chase Cancer Center
Target Recruit Count
17
Registration Number
NCT00021359
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Hunterdon Regional Cancer Center, Flemington, New Jersey, United States

๐Ÿ‡บ๐Ÿ‡ธ

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

๐Ÿ‡บ๐Ÿ‡ธ

Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County, Mount Holly, New Jersey, United States

and more 15 locations

Chemotherapy Before Autologous Stem Cell Transplantation +/- Rituximab in Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma

First Posted Date
2004-03-09
Last Posted Date
2023-08-23
Lead Sponsor
NCIC Clinical Trials Group
Target Recruit Count
849
Registration Number
NCT00078949
Locations
๐Ÿ‡จ๐Ÿ‡ฆ

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

๐Ÿ‡บ๐Ÿ‡ธ

Indiana University Medical Center, Indianapolis, Indiana, United States

๐Ÿ‡บ๐Ÿ‡ธ

University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States

and more 24 locations

Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia

Phase 2
Conditions
First Posted Date
2004-02-16
Last Posted Date
2013-09-17
Lead Sponsor
Johann Wolfgang Goethe University Hospital
Registration Number
NCT00002531
Locations
๐Ÿ‡ฉ๐Ÿ‡ช

Klinikum der J.W. Goethe Universitaet, Frankfurt, Germany

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

Phase 2
Conditions
First Posted Date
2004-02-16
Last Posted Date
2013-08-07
Lead Sponsor
Hannover Medical School
Registration Number
NCT00002532
Locations
๐Ÿ‡ฉ๐Ÿ‡ช

Medizinische Hochschule Hannover, Hannover, Germany

Interferon Alfa Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Multiple Myeloma

First Posted Date
2004-01-22
Last Posted Date
2013-06-26
Lead Sponsor
University of Tennessee
Registration Number
NCT00003007
Locations
๐Ÿ‡บ๐Ÿ‡ธ

William F. Bowld Hospital, Memphis, Tennessee, United States

๐Ÿ‡บ๐Ÿ‡ธ

Methodist Healthcare - Hospital of Memphis, Memphis, Tennessee, United States

๐Ÿ‡บ๐Ÿ‡ธ

Baptist Memorial Hospital, Memphis, Tennessee, United States

and more 1 locations

Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

First Posted Date
2004-01-13
Last Posted Date
2021-04-27
Lead Sponsor
Children's Oncology Group
Target Recruit Count
3154
Registration Number
NCT00075725
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States

๐Ÿ‡บ๐Ÿ‡ธ

Rush University Medical Center, Chicago, Illinois, United States

๐Ÿ‡บ๐Ÿ‡ธ

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States

and more 231 locations

Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102)

First Posted Date
2004-01-13
Last Posted Date
2021-11-01
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Target Recruit Count
710
Registration Number
NCT00075829
Locations
๐Ÿ‡บ๐Ÿ‡ธ

DFCI/Brigham & Women's, Boston, Massachusetts, United States

๐Ÿ‡บ๐Ÿ‡ธ

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

๐Ÿ‡บ๐Ÿ‡ธ

University of Minnesota, Minneapolis, Minnesota, United States

and more 33 locations

Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma

Phase 2
Completed
Conditions
First Posted Date
2003-12-11
Last Posted Date
2017-04-21
Lead Sponsor
OHSU Knight Cancer Institute
Target Recruit Count
22
Registration Number
NCT00074178
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Oregon Health & Science University Cancer Institute, Portland, Oregon, United States

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