Sirolimus
- Generic Name
- Sirolimus
- Brand Names
- Fyarro, Hyftor, Rapamune
- Drug Type
- Small Molecule
- Chemical Formula
- C51H79NO13
- CAS Number
- 53123-88-9
- Unique Ingredient Identifier
- W36ZG6FT64
- Background
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive a...
- Indication
Sirolimus is indicated for the prophylaxis of organ rejection in patients aged 13 years or older receiving renal transplants. In patients at low-to moderate-immunologic risk, it is recommended that sirolimus be used initially in a regimen with cyclosporine and corticosteroids; cyclosporine should be withdrawn two to four months after transplantation. In pati...
- Associated Conditions
- Chordomas, Facial Angiofibroma, Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Lymphangioleiomyomatosis (LAM), Renal Angiomyolipomas, Transplanted Organ Rejection, Metastatic malignant Perivascular Epithelioid Cell Neoplasms, Unresectable, locally advanced malignant Perivascular Epithelioid Cell Neoplasms
- Associated Therapies
- -
Islet Transplantation for Type 1 Diabetes
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2017-03-15
- Target Recruit Count
- 36
- Registration Number
- NCT00014911
- Locations
- 🇩🇪
Justus-Leibig University, Giessen, Germany
🇨🇦University of Alberta, Edmonton, Alberta, Canada
🇨🇭University of Geneva, Geneva, Switzerland
Pediatric Kidney Transplant Without Calcineurin Inhibitors
- Conditions
- Interventions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2016-10-21
- Target Recruit Count
- 35
- Registration Number
- NCT00023231
- Locations
- 🇺🇸
Lauren Schenker, Rockville, Maryland, United States
Sirolimus and Thymoglobulin to Prevent Kidney Transplant Rejection
- First Posted Date
- 2000-08-16
- Last Posted Date
- 2019-09-17
- Target Recruit Count
- 12
- Registration Number
- NCT00006178
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Drug Development Updates
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