Metamizole

Generic Name
Metamizole
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C13H17N3O4S
CAS Number
50567-35-6
Unique Ingredient Identifier
934T64RMNJ
Background

Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability. Metamizole was formerly marketed in the US as Dimethone tablets and injection, Protemp oral liquid, and other drug products, and was withdrawn due to its associati...

Indication

Metamizole is banned in several countries, where it was previously used as a powerful analgesic and fever reducer. In countries where it is still available, metamizole is indicated for acute severe pain after injuries or surgeries, colic, tumor pain, and acute or severe pain symptoms, as well as high fever if other treatments are unsuccessful.

Associated Conditions
Severe Pain, Severe Fever
Associated Therapies
-
Clinical Trials
Related News

Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars

First Posted Date
2024-02-01
Last Posted Date
2024-02-20
Lead Sponsor
EMS
Target Recruit Count
252
Registration Number
NCT06237231

Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain

First Posted Date
2021-11-18
Last Posted Date
2023-09-08
Lead Sponsor
EMS
Registration Number
NCT05125978

Postoperative Pain in Scheduled Craniotomy

First Posted Date
2021-01-22
Last Posted Date
2021-08-18
Lead Sponsor
Dr. Negrin University Hospital
Target Recruit Count
73
Registration Number
NCT04720248
Locations
🇪🇸

Ángel Becerra, Las Palmas De Gran Canaria, Las Palmas, Spain

Evaluation of the Added Value of Metamizole to Standard Postoperative Treatment After Ambulant Shoulder Surgery

Not Applicable
Completed
Conditions
Postoperative Pain
Analgesia
Surgery
Interventions
Drug: Placebo
Drug: Metamizole
First Posted Date
2021-01-11
Last Posted Date
2023-01-06
Lead Sponsor
Jessa Hospital
Target Recruit Count
110
Registration Number
NCT04703257
Locations
🇧🇪

Anesthesiology Jessa hospital, Hasselt, Belgium

Impact of Intra- and Postoperative Continuous Infusion of Lidocaine on Analgesia in Vascular Anaesthesia

First Posted Date
2020-12-31
Last Posted Date
2022-12-21
Lead Sponsor
Łukasz Krzych
Target Recruit Count
87
Registration Number
NCT04691726
Locations
🇵🇱

Leszek Giec Upper-Silesia Medical Center of the Medical University of Silesia in Katowice, Katowice, Poland

Fixed Combination of Dipirone and Codeine Compared to the Isolated Use of Dipyrone and Codeine in Controlling Pain After Pelvic-abdominal Surgery.

First Posted Date
2020-11-23
Last Posted Date
2024-06-27
Lead Sponsor
Brazilian Clinical Research Institute
Target Recruit Count
491
Registration Number
NCT04641338
Locations
🇧🇷

Santa Casa de Misericórdia de Votuporanga, Votuporanga, São Paulo, Brazil

🇧🇷

Hospital Universitário São Francisco na Providência de Deus, Bragança Paulista, São Paulo, Brazil

🇧🇷

Associação Hospital de Caridade Ijuí - Núcleo de Ensino e Pesquisa, Ijuí, Rio Grande Do Sul, Brazil

Inhibition Metamizole 2020

Phase 1
Completed
Conditions
Drug-drug Interaction
Interventions
Drug: Novalgin
First Posted Date
2020-11-09
Last Posted Date
2020-11-09
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
12
Registration Number
NCT04621253
Locations
🇨🇭

University Hospital, Basel, Switzerland

Efficacy and Safety of Tiradentes Association in the Treatment of Acute Pain

First Posted Date
2020-10-20
Last Posted Date
2023-09-08
Lead Sponsor
EMS
Registration Number
NCT04593329

Evaluation of the Added Value of Metamizole to Standard Post-operative Treatment After Ambulant Surgery

Not Applicable
Completed
Conditions
Surgery
Analgesia
Recovery
Interventions
Drug: Placebo oral tablet
Drug: Metamizole
First Posted Date
2019-09-09
Last Posted Date
2022-02-08
Lead Sponsor
Jessa Hospital
Target Recruit Count
110
Registration Number
NCT04082728
Locations
🇧🇪

Jessa Hospital, Hasselt, Limburg, Belgium

Pharmacokinetic Interactions of Metamizole (Dipyrone) in Healthy Subjects

Phase 1
Completed
Conditions
Inhibition
Induction
Drug-Drug Interaction
Interventions
Drug: Metamizole
First Posted Date
2019-06-18
Last Posted Date
2019-06-20
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
12
Registration Number
NCT03990129
Locations
🇨🇭

Clinical Trial Unit, University Hospital Basel, Basel, BS, Switzerland

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