Capsaicin

Generic Name: Capsaicin

Brand Names: Capzasin Quick Relief, Capzasin-HP, Castiva Warming, Dendracin Neurodendraxcin, Lidopro, Medi-derm, Medi-derm With Lidocaine, Medrox, Qutenza, Rematex, Xoten-C, Zostrix

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₇NO_₃

CAS Number: 404-86-4

Unique Ingredient Identifier: S07O44R1ZM

Background: Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.

Indication: The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.

Associated Conditions: Back Pain Lower Back, Back pain, Bursitis, Contusions, Inflammatory Reaction caused by Rheumatism, Muscle Cramps, Musculoskeletal Pain, Neuropathic Pain, Osteoarthritis (OA), Pain caused by Rheumatism, Periarthritis, Soft Tissue Injury, Tendinitis, Acute nonspecific tenosynovitis, Articular inflammation

Clinical Trials

Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain

Phase 2

Completed

Conditions: Osteoarthritis

Interventions: Other: Placebo
Drug: CNTX-4975

First Posted Date: 2015-09-24

Last Posted Date: 2017-08-08

Lead Sponsor: Centrexion Therapeutics

Target Recruit Count: 175

Registration Number: NCT02558439

Locations: 🇺🇸
Advanced Arizona Clinical Research, Tucson, Arizona, United States
🇺🇸
Dream Team Clinical Research, LLC, Anaheim, California, United States
🇺🇸
TriWest Research Associates, El Cajon, California, United States

and more 17 locations

Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis

Phase 2

Completed

Conditions: Nonallergic Irritant Rhinitis

Interventions: Drug: Placebo
Drug: Capsaicin

First Posted Date: 2015-07-09

Last Posted Date: 2020-08-17

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 22

Registration Number: NCT02493257

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain

Not Applicable

Completed

Conditions: Spinal Cord Injuries
Neuropathic Pain

Interventions: Drug: Capsaicin 8% Patch
Drug: Low Dose Capsaicin 0.025% Well Patch

First Posted Date: 2015-05-12

Last Posted Date: 2023-01-26

Lead Sponsor: The University of Texas Health Science Center at San Antonio

Target Recruit Count: 11

Registration Number: NCT02441660

Locations: 🇺🇸
Audie Lee Murphy VA Hospital, San Antonio, Texas, United States

Cough According to Stimulus Type in PD

Phase 1

Completed

Conditions: Parkinson's Disease

Interventions: Drug: Capsaicin vapor
Other: fog
Radiation: Videofluoroscopic swallow evaluation
Device: Nebulizer

First Posted Date: 2015-03-17

Last Posted Date: 2019-02-15

Lead Sponsor: University of Florida

Target Recruit Count: 158

Registration Number: NCT02390089

Locations: 🇺🇸
University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States

Chest Pain Perception and Capsaicin Sensitivity in Patients With Acute Cardiac Ischemia

Not Applicable

Completed

Conditions: Chest Pain

Interventions: Drug: Capsaicin

First Posted Date: 2015-01-27

Last Posted Date: 2021-03-04

Lead Sponsor: Bassett Healthcare

Target Recruit Count: 22

Registration Number: NCT02346916

Locations: 🇺🇸
Bassett Healthcare Network, Cooperstown, New York, United States

Chest Pain Perception and Capsaicin Sensitivity

Not Applicable

Completed

Conditions: Chest Pain

Interventions: Drug: Capsaicin

First Posted Date: 2015-01-27

Last Posted Date: 2021-03-04

Lead Sponsor: Bassett Healthcare

Target Recruit Count: 99

Registration Number: NCT02346903

Locations: 🇺🇸
Bassett Healthcare Network, Cooperstown, New York, United States

Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis

Phase 4

Completed

Conditions: Non-allergic Rhinitis

Interventions: Drug: placebo
Drug: Capsaicin

First Posted Date: 2014-11-11

Last Posted Date: 2021-06-22

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 80

Registration Number: NCT02288156

Locations: 🇧🇪
ORL, Leuven, Vlaams-Brabant, Belgium

A Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)

Phase 2

Completed

Conditions: Painful Intermetatarsal Neuroma (Morton's Neuroma)

Interventions: Drug: CNTX-4975
Other: Placebo

First Posted Date: 2014-11-05

Last Posted Date: 2016-12-06

Lead Sponsor: Centrexion Therapeutics

Target Recruit Count: 119

Registration Number: NCT02283957

Locations: 🇺🇸
eStudySite, La Mesa, La Mesa, California, United States
🇺🇸
Chesapeake Research Group, LLC, Pasadena, Maryland, United States
🇺🇸
University Orthopedics Center- Altoona, Altoona, Pennsylvania, United States

and more 12 locations

Assessment of Dystussia in Traumatic Brain Injury

Early Phase 1

Completed

Conditions: TBI
Brain Injury

Interventions: Behavioral: Neuropsychological Testing and Measures of TBI severity
Behavioral: Respiratory measures
Drug: Capsaicin cough sensitivity testing