Capsaicin
- Generic Name
- Capsaicin
- Brand Names
- Capzasin Quick Relief, Capzasin-HP, Castiva Warming, Dendracin Neurodendraxcin, Lidopro, Medi-derm, Medi-derm With Lidocaine, Medrox, Qutenza, Rematex, Xoten-C, Zostrix
- Drug Type
- Small Molecule
- Chemical Formula
- C18H27NO3
- CAS Number
- 404-86-4
- Unique Ingredient Identifier
- S07O44R1ZM
- Background
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
- Indication
The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
- Associated Conditions
- Back Pain Lower Back, Back pain, Bursitis, Contusions, Inflammatory Reaction caused by Rheumatism, Muscle Cramps, Musculoskeletal Pain, Neuropathic Pain, Osteoarthritis (OA), Pain caused by Rheumatism, Periarthritis, Soft Tissue Injury, Tendinitis, Acute nonspecific tenosynovitis, Articular inflammation
A Study to Evaluate the Long-term Safety of Repeated QUTENZA Administration for Treatment of Pain Caused by Nerve Damage in Diabetic Patients
- First Posted Date
- 2011-11-23
- Last Posted Date
- 2015-10-14
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 468
- Registration Number
- NCT01478607
- Locations
- 🇺🇦
Site: 806, Kyiv, Ukraine
🇺🇦Site: 802, Mykolayiv, Ukraine
🇵🇱Site: 954, Katowice, Poland
Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch
- Conditions
- or Peripheral Nerve Injury (PNI)Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN)
- Interventions
- First Posted Date
- 2011-08-12
- Last Posted Date
- 2018-04-23
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 122
- Registration Number
- NCT01416116
- Locations
- 🇧🇪
Site 102, Antwerpen, Belgium
🇧🇪Site 103, Genk, Belgium
🇧🇪Site 101, Roeselare, Belgium
Qutenza®-Remodulin® in Pulmonary Arterial Hypertension Patients
- First Posted Date
- 2011-07-13
- Last Posted Date
- 2023-10-05
- Lead Sponsor
- Imperial College London
- Target Recruit Count
- 11
- Registration Number
- NCT01393795
- Locations
- 🇬🇧
Hammersmith Hospital, Imperial College NHS Trust, London, United Kingdom
The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain
- Conditions
- Pulmonary HypertensionPulmonary Arterial Hypertension
- Interventions
- First Posted Date
- 2010-12-15
- Last Posted Date
- 2016-04-21
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 6
- Registration Number
- NCT01260454
- Locations
- 🇺🇸
Mary M. Parkes Asthma Center, University of Rochester, Rochester, New York, United States
Safety and Effectiveness of Repeated Administration of QUTENZA Patches for Treatment of Pain Caused by Nerve Damage
- First Posted Date
- 2010-12-02
- Last Posted Date
- 2018-04-19
- Lead Sponsor
- Astellas Pharma Inc
- Target Recruit Count
- 306
- Registration Number
- NCT01252160
Efficacy of Topical Capsaicin Cream for Stable Angina
- First Posted Date
- 2010-11-01
- Last Posted Date
- 2015-06-25
- Lead Sponsor
- Neal Weintraub
- Target Recruit Count
- 7
- Registration Number
- NCT01231750
- Locations
- 🇺🇸
University of Cincinnati Physicians, Inc, Cincinnati, Ohio, United States
Neuro-immunological Analysis of Idiopathic Rhinitis Patients and Controls Treated With Capsaicin.
- First Posted Date
- 2010-10-19
- Last Posted Date
- 2011-10-03
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 36
- Registration Number
- NCT01223820
- Locations
- 🇧🇪
UZ Leuven, NKO-GH Kapucijnenvoer 33, Leuven, Vlaams-Brabant, Belgium
Efficacy of Topical Capsaicin on Chronic Neck Pain
- First Posted Date
- 2010-09-14
- Last Posted Date
- 2010-09-14
- Lead Sponsor
- Kyunghee University Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT01200745
- Locations
- 🇰🇷
Kyunghee University East West Neo Medical Center, Seoul, Korea, Republic of
Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy
- First Posted Date
- 2009-10-09
- Last Posted Date
- 2012-05-09
- Lead Sponsor
- Thammasat University
- Target Recruit Count
- 33
- Registration Number
- NCT00993070
- Locations
- 🇹🇭
Thammasat University Hospital, Pathumthani, Thailand
Study of NGX-4010 With the Use of Open Label Lidocaine (2.5%)/Prilocaine (2.5%) Cream for the Treatment of Postherpetic Neuralgia (PHN)
- Conditions
- Postherpetic Neuralgia
- Interventions
- First Posted Date
- 2009-06-10
- Last Posted Date
- 2009-09-09
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 20
- Registration Number
- NCT00916942
- Locations
- 🇺🇸
Comprehensive NeuroScience, Inc., St. Petersburg, Florida, United States
🇺🇸Anchor Research Center, Naples, Florida, United States
🇺🇸Lifetree Clinical Research, Salt Lake City, Utah, United States
Drug Development Updates
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