Capsaicin
- Generic Name
- Capsaicin
- Brand Names
- Capzasin Quick Relief, Capzasin-HP, Castiva Warming, Dendracin Neurodendraxcin, Lidopro, Medi-derm, Medi-derm With Lidocaine, Medrox, Qutenza, Rematex, Xoten-C, Zostrix
- Drug Type
- Small Molecule
- Chemical Formula
- C18H27NO3
- CAS Number
- 404-86-4
- Unique Ingredient Identifier
- S07O44R1ZM
- Background
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
- Indication
The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
- Associated Conditions
- Back Pain Lower Back, Back pain, Bursitis, Contusions, Inflammatory Reaction caused by Rheumatism, Muscle Cramps, Musculoskeletal Pain, Neuropathic Pain, Osteoarthritis (OA), Pain caused by Rheumatism, Periarthritis, Soft Tissue Injury, Tendinitis, Acute nonspecific tenosynovitis, Articular inflammation
Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
- Conditions
- Peripheral Nervous System DiseasesPainNeuralgiaHerpes ZosterShingles
- First Posted Date
- 2006-03-08
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 400
- Registration Number
- NCT00300222
Effect of NGX-4010 on ENFD and Sensory Function
- Conditions
- Human Volunteers
- First Posted Date
- 2005-11-16
- Last Posted Date
- 2009-02-16
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 36
- Registration Number
- NCT00254449
- Locations
- 🇺🇸
NeurogesX Investigational Site, Minneapolis, Minnesota, United States
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)
- Conditions
- Herpes ZosterNeuralgiaPainHIV InfectionsPeripheral Nervous System Diseases
- First Posted Date
- 2005-10-05
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 100
- Registration Number
- NCT00233155
Response of Topical Capsaicin in Alopecia Areata
- Conditions
- Alopecia Areata
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2014-06-02
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 24
- Registration Number
- NCT00176969
- Locations
- 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States
Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
- Conditions
- Healthy Volunteers
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2017-11-01
- Lead Sponsor
- University Hospital, Angers
- Target Recruit Count
- 85
- Registration Number
- NCT00152724
- Locations
- 🇫🇷
Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers, Angers, France
Efficacy and Safety of ALGRX 4975 in Treatment of Postoperative Pain After Hernia Repair
- Conditions
- Postoperative Pain
- First Posted Date
- 2005-09-07
- Last Posted Date
- 2006-12-20
- Lead Sponsor
- AlgoRx Pharmaceuticals
- Target Recruit Count
- 40
- Registration Number
- NCT00146198
- Locations
- 🇩🇰
Dagkirurgisk Klinik, Hørsholm, Denmark
Efficacy and Safety of ALGRX 4975 in the Treatment of Postoperative Pain After Gall Bladder Removal
- Conditions
- Postoperative Pain
- First Posted Date
- 2005-08-22
- Last Posted Date
- 2006-12-20
- Lead Sponsor
- AlgoRx Pharmaceuticals
- Target Recruit Count
- 40
- Registration Number
- NCT00133133
- Locations
Emergency Center, Clinical Center of Serbia, Belgrade, Former Serbia and Montenegro
ALGRX 4975 After Total Knee Replacement
- Conditions
- Arthroplasty, Replacement, KneeKnee Injuries
- First Posted Date
- 2005-08-22
- Last Posted Date
- 2006-12-20
- Lead Sponsor
- AlgoRx Pharmaceuticals
- Target Recruit Count
- 40
- Registration Number
- NCT00132392
- Locations
- 🇺🇸
Capstone Clinical Trials, Inc., Birmingham, Alabama, United States
ALGRX 4975 in the Treatment of Tennis Elbow
- Conditions
- Tennis Elbow
- First Posted Date
- 2005-08-17
- Last Posted Date
- 2006-12-20
- Lead Sponsor
- AlgoRx Pharmaceuticals
- Target Recruit Count
- 45
- Registration Number
- NCT00130949
- Locations
- 🇸🇰
Ortopedicko-Traumatologicka Klinika, Kosice, Slovakia
ALGRX 4975 in the Treatment of Patients With Morton's Neuroma
- Conditions
- Neuroma
- First Posted Date
- 2005-08-17
- Last Posted Date
- 2005-10-03
- Lead Sponsor
- AlgoRx Pharmaceuticals
- Target Recruit Count
- 60
- Registration Number
- NCT00130962
- Locations
- 🇺🇸
Crossroads Research, Inc., Owings Mills, Maryland, United States
🇺🇸Jean Brown Research, Salt Lake City, Utah, United States
Drug Development Updates
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