Capsaicin
- Generic Name
- Capsaicin
- Brand Names
- Capzasin Quick Relief, Capzasin-HP, Castiva Warming, Dendracin Neurodendraxcin, Lidopro, Medi-derm, Medi-derm With Lidocaine, Medrox, Qutenza, Rematex, Xoten-C, Zostrix
- Drug Type
- Small Molecule
- Chemical Formula
- C18H27NO3
- CAS Number
- 404-86-4
- Unique Ingredient Identifier
- S07O44R1ZM
- Background
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
- Indication
The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
- Associated Conditions
- Back Pain Lower Back, Back pain, Bursitis, Contusions, Inflammatory Reaction caused by Rheumatism, Muscle Cramps, Musculoskeletal Pain, Neuropathic Pain, Osteoarthritis (OA), Pain caused by Rheumatism, Periarthritis, Soft Tissue Injury, Tendinitis, Acute nonspecific tenosynovitis, Articular inflammation
Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
- Conditions
- PainShinglesPeripheral Nervous System DiseasesNeuralgiaHerpes Zoster
- First Posted Date
- 2005-06-22
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 400
- Registration Number
- NCT00115310
An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain
- Conditions
- Herpes ZosterNeuralgiaPainHIV InfectionsPeripheral Nervous System DiseasesDiabetic NeuropathiesDiabetes MellitusPolyneuropathies
- First Posted Date
- 2004-08-09
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- NeurogesX
- Registration Number
- NCT00089557
Capsaicin to Control Pain Following Third Molar Extraction
- Conditions
- HealthyTooth Extraction
- First Posted Date
- 2004-08-02
- Last Posted Date
- 2008-03-04
- Lead Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
- Target Recruit Count
- 75
- Registration Number
- NCT00088686
- Locations
- 🇺🇸
National Institute of Dental And Craniofacial Research (NIDCR), Bethesda, Maryland, United States
Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy
- Conditions
- HIV InfectionsPeripheral Nervous System DiseasesPain
- First Posted Date
- 2004-06-17
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Registration Number
- NCT00085761
- Locations
- 🇺🇸
NeurogesX Investigational Site, Annandale, Virginia, United States
Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain
- Conditions
- Herpes ZosterDiabetic NeuropathiesNeuralgiaPolyneuropathiesPainDiabetes MellitusHIV InfectionsPeripheral Nervous System Diseases
- First Posted Date
- 2004-05-07
- Last Posted Date
- 2008-01-11
- Lead Sponsor
- NeurogesX
- Registration Number
- NCT00082316
- Locations
- 🇺🇸
NeurogesX Investigational Site, Salt Lake City, Utah, United States
Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
- Conditions
- Herpes ZosterNeuralgiaPainPeripheral Nervous System Diseases
- First Posted Date
- 2003-09-09
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 150
- Registration Number
- NCT00068081
- Locations
- 🇺🇸
NeurogesX Investigational Site, Salt Lake City, Utah, United States
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy
- Conditions
- HIV InfectionsPeripheral Nervous System DiseasesPain
- First Posted Date
- 2003-07-11
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 300
- Registration Number
- NCT00064623
- Locations
- 🇺🇸
NeurogesX Investigational Site, Madison, Wisconsin, United States
NGX-4010 for the Treatment of Postherpetic Neuralgia
- Conditions
- Herpes ZosterNeuralgiaPainPeripheral Nervous System DiseasesShingles
- First Posted Date
- 2003-06-04
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 300
- Registration Number
- NCT00061776
- Locations
- 🇺🇸
NeurogesX Investigational Site, Tacoma, Washington, United States
Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy
- Conditions
- HIV Infections
- First Posted Date
- 2003-05-22
- Last Posted Date
- 2007-09-14
- Lead Sponsor
- NeurogesX
- Registration Number
- NCT00061152
- Locations
- 🇺🇸
NeurogesX Investigational Site, Portland, Oregon, United States
Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain
- Conditions
- NeuralgiaPainPeripheral Nervous System DiseasesHerpes Zoster
- First Posted Date
- 2002-05-02
- Last Posted Date
- 2006-02-07
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 42
- Registration Number
- NCT00034710
- Locations
- 🇺🇸
University of Utah Pain Management Center, Salt Lake City, Utah, United States
🇺🇸Brigham and Women's Hospital, Pain Trials Center, Boston, Massachusetts, United States
🇺🇸Arizona Research Center, Phoenix, Arizona, United States
Drug Development Updates
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