Capsaicin
- Generic Name
- Capsaicin
- Brand Names
- Capzasin Quick Relief, Capzasin-HP, Castiva Warming, Dendracin Neurodendraxcin, Lidopro, Medi-derm, Medi-derm With Lidocaine, Medrox, Qutenza, Rematex, Xoten-C, Zostrix
- Drug Type
- Small Molecule
- Chemical Formula
- C18H27NO3
- CAS Number
- 404-86-4
- Unique Ingredient Identifier
- S07O44R1ZM
- Background
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
- Indication
The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
- Associated Conditions
- Back Pain Lower Back, Back pain, Bursitis, Contusions, Inflammatory Reaction caused by Rheumatism, Muscle Cramps, Musculoskeletal Pain, Neuropathic Pain, Osteoarthritis (OA), Pain caused by Rheumatism, Periarthritis, Soft Tissue Injury, Tendinitis, Acute nonspecific tenosynovitis, Articular inflammation
A Study to Investigate the Tolerability and Effects on Epidermal Nerve Fiber Density of Multiple Low-Concentrations of NGX-1998 in Healthy Volunteers
- First Posted Date
- 2009-06-03
- Last Posted Date
- 2009-06-03
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 36
- Registration Number
- NCT00912262
- Locations
- 🇺🇸
Lifetree Clinical Research, Salt Lake City, Utah, United States
Trial to Evaluate the Efficacy of Topical Capsaicin to Reduce Pain and Improve Health-related Quality of Life in Adults With Chronic Myofascial Neck Pain
- First Posted Date
- 2008-11-21
- Last Posted Date
- 2016-12-06
- Lead Sponsor
- Stamford Hospital
- Registration Number
- NCT00795106
- Locations
- 🇺🇸
Stamford Hospital, Stamford, Connecticut, United States
Cervical Capsaicin for Labor Induction and Pain Relief
- Conditions
- Labor PainPregnancy LossLabor Induction
- Interventions
- Drug: Placebo
- First Posted Date
- 2008-10-13
- Last Posted Date
- 2021-08-09
- Lead Sponsor
- Columbia University
- Registration Number
- NCT00771511
Effects of Capsaicin on the Structure, Distribution, and Function of Cutaneous Small Nerve Fibers in Psoriatic Skin
- First Posted Date
- 2008-06-13
- Last Posted Date
- 2018-08-13
- Lead Sponsor
- Wake Forest University
- Target Recruit Count
- 12
- Registration Number
- NCT00697034
- Locations
- 🇺🇸
Wake Forest University Health Sciences Dermatology, Winston-Salem, North Carolina, United States
Effect of Spinal Ketorolac After Acute Opioid Exposure
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2008-06-06
- Last Posted Date
- 2018-09-07
- Lead Sponsor
- Wake Forest University
- Target Recruit Count
- 30
- Registration Number
- NCT00693160
- Locations
- 🇺🇸
Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States
Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA)
- First Posted Date
- 2008-04-28
- Last Posted Date
- 2016-12-06
- Lead Sponsor
- Centrexion Therapeutics
- Target Recruit Count
- 54
- Registration Number
- NCT00667654
- Locations
- 🇺🇸
Clinical Phamacology Study Group, Worcester, Massachusetts, United States
Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects
- First Posted Date
- 2008-04-10
- Last Posted Date
- 2018-09-10
- Lead Sponsor
- Wake Forest University
- Target Recruit Count
- 40
- Registration Number
- NCT00655811
- Locations
- 🇺🇸
Wake Forest University Health Sciences Dermatology, Winston-Salem, North Carolina, United States
Sensory Function After Wound Instillation of Capsaicin
- First Posted Date
- 2007-12-31
- Last Posted Date
- 2008-01-30
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 42
- Registration Number
- NCT00583180
- Locations
- 🇩🇰
Hørshol Sygehus, Hørsholm, Denmark
Study of Three Capsaicin Dermal Liquid Formulations on Epidermal Nerve Fiber Immunostaining and Sensory Function
- Conditions
- Pain
- First Posted Date
- 2007-09-12
- Last Posted Date
- 2008-03-06
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 20
- Registration Number
- NCT00528216
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy
- Conditions
- Peripheral Nervous System DiseasesHIV InfectionsPain
- Interventions
- First Posted Date
- 2006-05-04
- Last Posted Date
- 2011-06-14
- Lead Sponsor
- NeurogesX
- Target Recruit Count
- 494
- Registration Number
- NCT00321672
Drug Development Updates
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