Lamotrigine
- Generic Name
- Lamotrigine
- Brand Names
- Lamictal
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7Cl2N5
- CAS Number
- 84057-84-1
- Unique Ingredient Identifier
- U3H27498KS
- Background
Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 cou...
- Indication
Lamotrigine is indicated as adjunctive therapy for the following seizure types in patients ≥2 years of age: partial seizures, primary generalized tonic-clonic seizures, and generalized seizures due to Lennox-Gastaut syndrome.
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- Associated Conditions
- Bipolar 1 Disorder, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Seizures, Generalized
- Associated Therapies
- Conversion to monotherapy
A Bioequivalence Study of Two Formulations Lamotrigine 100 mg Tablets and Lamictal 100 mg Tablets in Healthy Adult Volunteers Under Fasting Conditions
- First Posted Date
- 2019-04-01
- Last Posted Date
- 2019-06-06
- Lead Sponsor
- Pharmtechnology LLC
- Target Recruit Count
- 28
- Registration Number
- NCT03898011
- Locations
- 🇷🇺
State Autonomous Healthcare Facility of the Yaroslavl Region "Clinical Hospital No. 2", Yaroslavl, Yaroslavl Region, Russian Federation
A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women
- Conditions
- Interventions
- First Posted Date
- 2018-12-13
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 20
- Registration Number
- NCT03774641
- Locations
- 🇺🇸
550 N Broadway, Baltimore, Maryland, United States
A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil
- Conditions
- Interventions
- First Posted Date
- 2018-10-03
- Last Posted Date
- 2020-06-04
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 31
- Registration Number
- NCT03695094
- Locations
- 🇳🇱
Up0070 401, Leiden, Netherlands
🇧🇬Up0070 101, Sofia, Bulgaria
Synaptic Plasticity and Cognitive Function in RASopathies
- Conditions
- Interventions
- First Posted Date
- 2018-04-20
- Last Posted Date
- 2023-11-30
- Lead Sponsor
- Technical University of Munich
- Target Recruit Count
- 16
- Registration Number
- NCT03504501
- Locations
- 🇩🇪
Technical University Munich, Munich, Germany
Bariatric Surgery and Pharmacokinetics of Lamotrigine
- Conditions
- First Posted Date
- 2018-04-13
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- Norwegian University of Science and Technology
- Target Recruit Count
- 12
- Registration Number
- NCT03497143
- Locations
- 🇳🇴
St. Olavs University Hospital, Trondheim, Norway
Protocol Establishment for the Prevention of Lamotrigine-induced Skin Rash in Epilepsy Patients
- First Posted Date
- 2017-07-18
- Last Posted Date
- 2017-07-18
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT03220256
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Population Pharmacokinetics of Antiepileptic in Pediatrics
- Conditions
- Interventions
- Biological: Valproic acidBiological: carbamazepineBiological: phenobarbitalBiological: phenytoinBiological: levetiracetamBiological: lamotrigineBiological: topiramateBiological: oxcarbazepineBiological: stiripentolBiological: clobazamBiological: brivaracétamBiological: felbamateBiological: lacosamideBiological: rufinamideBiological: gabapentineBiological: pregabalineBiological: sultiameBiological: tiagabineBiological: vigabatrineBiological: mesuximideBiological: primidoneBiological: perampanelBiological: ethosuximideBiological: zonisamideBiological: cannabidiolOther: genetic polymorphisms
- First Posted Date
- 2017-06-22
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 1000
- Registration Number
- NCT03196466
- Locations
- 🇫🇷
AP-HP Cochin, Paris, France
Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine
- Conditions
- Interventions
- First Posted Date
- 2016-12-12
- Last Posted Date
- 2019-02-15
- Lead Sponsor
- University of Saskatchewan
- Target Recruit Count
- 150
- Registration Number
- NCT02989727
- Locations
- 🇨🇦
Department of Psychiatry, Royal University Hospital, Saskatoon, Saskatchewan, Canada
Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies
- Conditions
- First Posted Date
- 2016-09-08
- Last Posted Date
- 2024-03-12
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 1037352
- Registration Number
- NCT02893371
- Locations
- 🇺🇸
Christophe G Lambert, Albuquerque, New Mexico, United States
The Sustained Effects of Ketamine
- Conditions
- Interventions
- First Posted Date
- 2016-03-15
- Last Posted Date
- 2020-07-02
- Lead Sponsor
- Yale University
- Target Recruit Count
- 3
- Registration Number
- NCT02708849
- Locations
- 🇺🇸
Yale Center for Clinical Investigation, Yale University, New Haven, Connecticut, United States
Drug Development Updates
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