Arsenic trioxide
- Generic Name
- Arsenic trioxide
- Brand Names
- Trisenox, Arsenic trioxide Accord, Arsenic trioxide Mylan, Arsenic trioxide medac
- Drug Type
- Small Molecule
- Chemical Formula
- As2O3
- CAS Number
- 1327-53-3
- Unique Ingredient Identifier
- S7V92P67HO
- Background
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredo...
- Indication
For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
- Associated Conditions
- Acute Promyelocytic Leukemia, Refractory Acute Promyelocytic Leukemia, Relapsed Acute Promyelocytic Leukemia
- Associated Therapies
- -
Arsenic Trioxide in Treating Young Patients With Refractory Leukemia or Lymphoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2015-04-29
- Lead Sponsor
- National Cancer Institute (NCI)
- Registration Number
- NCT00020111
- Locations
- 🇺🇸
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta, Georgia, United States
🇺🇸University of Mississippi Medical Center, Jackson, Mississippi, United States
🇺🇸Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, United States
Arsenic Trioxide and Dexamethasone in Treating Patients With Recurrent or Refractory Stage II or Stage III Multiple Myeloma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2020-10-05
- Lead Sponsor
- CTI BioPharma
- Registration Number
- NCT00017069
- Locations
- 🇺🇸
Mountain States Tumor Institute - Boise, Meridian, Idaho, United States
🇺🇸Texas Cancer Care, Fort Worth, Texas, United States
🇺🇸Rocky Mountain Cancer Centers - Midtown, Denver, Colorado, United States
Arsenic Trioxide in Treating Patients With Stage IV Prostate Cancer That Has Not Responded to Previous Hormone Therapy
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2018-08-17
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 37
- Registration Number
- NCT00004149
- Locations
- 🇺🇸
Jacobi Medical Center, Bronx, New York, United States
🇺🇸Mount Sinai Medical Center, NY, New York, New York, United States
🇺🇸Albert Einstein Clinical Cancer Center, Bronx, New York, United States
Arsenic Trioxide Plus Vitamin C in Treating Patients With Recurrent or Refractory Multiple Myeloma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2016-12-15
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 22
- Registration Number
- NCT00006021
- Locations
- 🇺🇸
University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida, United States
🇺🇸Mount Sinai Comprehensive Cancer Center at Mount Sinai Medical Center, Miami Beach, Florida, United States
🇺🇸Baptist-South Miami Regional Cancer Program, Miami, Florida, United States
Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2015-11-25
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 22
- Registration Number
- NCT00024258
- Locations
- 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Drug Development Updates
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