DeepMed Research

The Sidney Kimmel Comprehensive Cancer Center

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private, Subsidiary

Employees: -

Market Cap: -

Website: http://www.hopkinsmedicine.org/kimmel_cancer_center

Clinical Trials

Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer

Phase 2

Recruiting

Conditions: Prostate Cancer (Adenocarcinoma)
Metastatic Prostate Cancer

Interventions: Drug: Abiraterone acetate
Drug: Dexamethasone
Drug: Metronidazole

First Posted Date: 2024-09-27

Last Posted Date: 2025-03-05

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 58

Registration Number: NCT06616597

Locations: 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Feasibility of CSF and Plasma ctDNA in BRAF-altered Glioma During Treatment With Plixorafenib

Early Phase 1

Recruiting

Conditions: BRAF V600E Mutation

Interventions: Drug: Plixorafenib
Drug: Cobicistat 150 MG [Tybost]

First Posted Date: 2024-09-24

Last Posted Date: 2025-04-09

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 15

Registration Number: NCT06610682

Locations: 🇺🇸
Johns Hopkins, Baltimore, Maryland, United States

Targeting Driver Oncogenes With a Peptide Vaccine Plus Durvalumab and Tremelimumab for Patients With Biliary Tract Cancers (BTC)

Phase 1

Not yet recruiting

Conditions: Biliary Tract Cancers

Interventions: Drug: mBTC vax [0.3 - 2.4 mg peptide + 0.5 mg Poly-ICLC (Hiltonol)]
Drug: Durvalumab
Drug: Tremelimumab

First Posted Date: 2024-08-21

Last Posted Date: 2025-05-11

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 25

Registration Number: NCT06564623

Locations: 🇺🇸
SKCCC Johns Hopkins Medical Institution, Baltimore, Maryland, United States

Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming

Not Applicable

Recruiting

Conditions: Breast Cancer
Early-stage Breast Cancer

Interventions: Behavioral: Fasting

First Posted Date: 2024-08-05

Last Posted Date: 2024-08-26

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 30

Registration Number: NCT06536881

Locations: 🇺🇸
Sibley Memorial Hospital, Washington, District of Columbia, United States

Clinical Trial Assessing the Safety and Immunologic Correlates of Heterologous Prime-Boost With pNGVL4a-Sig/E7(Detox)/HSP70 and TA-HPV in Healthy Donors Followed by Peripheral Blood Collection

Phase 1

Conditions: Metastatic Cancer
HPV 16 Infection
HPV-Related Carcinoma
Recurrence

Interventions: Biological: pNGVL4a-Sig/E7(detox)/HSP70 plasmid DNA; TA-HPV vaccinia virus

First Posted Date: 2024-07-18

Last Posted Date: 2025-04-13

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 24

Registration Number: NCT06508138

Locations: 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Behavioral Weight Loss for Cancer Survivors in Maryland: A Trial With Adaptive Interventions

Not Applicable

Recruiting

Conditions: Weight Loss

Interventions: Behavioral: CORE Helpline
Behavioral: Extended Helpline
Behavioral: Enhanced Helpline
Behavioral: Intensive Helpline

First Posted Date: 2024-06-17

Last Posted Date: 2024-07-18

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 200

Registration Number: NCT06463249

Locations: 🇺🇸
Johns Hopkins ProHealth, Baltimore, Maryland, United States

Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma

Recruiting

Conditions: Chordoma of Sacrum
Chordoma of Skull Base
Chordoma of Spine

Interventions: Diagnostic Test: ctDNA

First Posted Date: 2024-06-17

Last Posted Date: 2024-07-25

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 40

Registration Number: NCT06463262

Locations: 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Phase 1

Recruiting

Conditions: Pancreatic Cancer
Colorectal Cancer

Interventions: Drug: KRAS Vaccine with Poly-ICLC adjuvant
Drug: Balstilimab
Drug: Botensilimab

First Posted Date: 2024-05-13

Last Posted Date: 2025-04-06

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 54

Registration Number: NCT06411691

Locations: 🇺🇸
Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Early Phase 1

Not yet recruiting

Conditions: Bone Marrow Transplant Rejection
Myelodysplastic Syndromes (MDS)
Aplastic Anemia
Hodgkin Lymphoma
Acute Myeloid Leukemia (AML)
Non Hodgkin Lymphoma
Myelofibrosis
Acute Lymphoblastic Leukemia (ALL), Adult
Hematologic Malignancy
Multiple Myeloma

Interventions: Drug: Darzalex Faspro (Daratumumab and hyaluronidase-fihj)
Device: JH-DSA Semi-Quant Screen and Response Score

First Posted Date: 2024-05-03

Last Posted Date: 2024-08-28

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 8

Registration Number: NCT06398457

Locations: 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

Recruiting

Conditions: Prostate Cancer
Advanced Cancer

Interventions: Radiation: 177Lu-DOTATATE
Radiation: Radium-223
Radiation: 177Lu-PSMA-617

First Posted Date: 2024-04-29

Last Posted Date: 2025-03-07

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 80

Registration Number: NCT06389097

Locations: 🇺🇸
Johns Hopkins University, Baltimore, Maryland, United States

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