University of Pennsylvania

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private

Established: 1740-11-14

Employees: 5K

Market Cap: -

Website: http://www.upenn.edu

Clinical Trials

Trauma Induced Coagulopathy and Inflammation

Completed

Conditions: Trauma Injury
Trauma
Coagulopathy

Interventions: Diagnostic Test: Thromboelastography
Diagnostic Test: Computational model

First Posted Date: 2017-04-25

Last Posted Date: 2021-03-09

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 300

Registration Number: NCT03128658

Locations: 🇺🇸
Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States

Accelerated TMS to a Novel Brain Target in MDD and PTSD

Not Applicable

Completed

Conditions: Major Depressive Disorder
Post Traumatic Stress Disorder

Interventions: Device: Transcranial Magnetic Stimulation (TMS)
Behavioral: Task
Procedure: fMRI-guided TMS target

First Posted Date: 2017-04-14

Last Posted Date: 2023-05-06

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 50

Registration Number: NCT03114891

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

MCI: CPAP Treatment of OSA (Memories2)

Not Applicable

Active, not recruiting

Conditions: Sleep Apnea, Obstructive
Mild Cognitive Impairment

Interventions: Device: CPAP

First Posted Date: 2017-04-13

Last Posted Date: 2023-04-12

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 327

Registration Number: NCT03113461

Locations: 🇺🇸
Washington University in St. Louis, Saint Louis, Missouri, United States
🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸
University of Texas at Austin, Austin, Texas, United States

and more 1 locations

Default Options to Reduce Unnecessary Daily Imaging During Palliative Radiation

Not Applicable

Completed

Conditions: Cancer

Interventions: Behavioral: Default initiation

First Posted Date: 2017-04-12

Last Posted Date: 2019-12-09

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 1188

Registration Number: NCT03110692

Locations: 🇺🇸
University of Pennsylvania Health System, Philadelphia, Pennsylvania, United States

Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A

Early Phase 1

Completed

Conditions: Bladder Pain Syndrome

Interventions: Drug: DMSO
Drug: Botox

First Posted Date: 2017-04-06

Last Posted Date: 2017-06-09

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 2

Registration Number: NCT03103594

Novel Neural Circuit Biomarkers of Major Depression Response to CCBT

Not Applicable

Completed

Conditions: Depression, Unipolar
Depressive Disorder
Depression
Major Depressive Disorder

Interventions: Behavioral: Computer-Augmented Cognitive Behavioral Therapy

First Posted Date: 2017-03-30

Last Posted Date: 2024-12-05

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 132

Registration Number: NCT03096886

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

Dendritic Cell Vaccination in Patients With Advanced Melanoma

Phase 1

Completed

Conditions: Melanoma

Interventions: Biological: Mature dendritic cell (DC) vaccine
Drug: Cyclophosphamide 300mg/m^2
Drug: Pembrolizumab

First Posted Date: 2017-03-28

Last Posted Date: 2024-12-24

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 5

Registration Number: NCT03092453

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

CART-PSMA-TGFβRDN Cells for Castrate-Resistant Prostate Cancer

Phase 1

Active, not recruiting

Conditions: Prostate Cancer

Interventions: Biological: CART-PSMA-TGFβRDN cells
Drug: Cyclophosphamide
Drug: Fludarabine

First Posted Date: 2017-03-24

Last Posted Date: 2025-05-14

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 23

Registration Number: NCT03089203

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

Vascular Inflammation in Psoriasis - Apremilast

Phase 4

Completed

Conditions: Psoriasis
Cardiovascular Diseases

Interventions: Drug: Apremilast

First Posted Date: 2017-03-17

Last Posted Date: 2022-11-10

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 70

Registration Number: NCT03082729

Locations: 🇺🇸
University of Southern California, Los Angeles, California, United States
🇺🇸
Center for Clinical Studies, Houston, Texas, United States
🇺🇸
Oregon Medical Research Center, Portland, Oregon, United States

and more 4 locations

Migraine and CVD Risk in Women

Not Applicable

Active, not recruiting

Conditions: Migraine

Interventions: Other: Mixed meal tolerance testing
Other: Skin conductance & cold pressor test
Other: Flow-mediated dilation testing

First Posted Date: 2017-03-16

Last Posted Date: 2023-09-28

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 30

Registration Number: NCT03081390

Locations: 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States

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