NATIONAL INSTITUTES OF HEALTH

🇺🇸United States

Country: 🇺🇸United States

Ownership: Subsidiary, Private

Established: 1948-01-01

Employees: 1K

Market Cap: -

Website: http://www.nidcr.nih.gov

Clinical Trials

Optimal Methods of Disease Detection in Children and Young Adults With Acute Lymphoblastic Leukemia in the Pediatric Oncology Branch

Completed

Conditions: Leukemia, Lymphoblastic, Acute
ALL, Childhood

First Posted Date: 2018-08-13

Last Posted Date: 2022-06-01

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 150

Registration Number: NCT03627208

Locations: 🇺🇸
National Cancer Institute (NCI), Bethesda, Maryland, United States

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

Phase 2

Recruiting

Conditions: Anatomic Stage IV Breast Cancer AJCC v8
Invasive Breast Carcinoma
Metastatic Triple-Negative Breast Carcinoma

Interventions: Procedure: Biopsy Procedure
Procedure: Biospecimen Collection
Drug: Carboplatin
Procedure: Computed Tomography
Biological: Durvalumab
Drug: Gemcitabine Hydrochloride
Procedure: Magnetic Resonance Imaging
Drug: Nab-paclitaxel
Biological: Personalized Synthetic Long Peptide Vaccine
Drug: Poly ICLC
Biological: Sacituzumab Govitecan
Biological: Tremelimumab

First Posted Date: 2018-07-31

Last Posted Date: 2025-04-23

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 70

Registration Number: NCT03606967

Locations: 🇺🇸
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States
🇺🇸
University of California Davis Comprehensive Cancer Center, Sacramento, California, United States
🇺🇸
UCHealth University of Colorado Hospital, Aurora, Colorado, United States

and more 27 locations

Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

Phase 1

Active, not recruiting

Conditions: Recurrent Meningioma
Grade 3 Meningioma
Grade 2 Meningioma

Interventions: Procedure: Biospecimen Collection
Procedure: Echocardiography Test
Procedure: Magnetic Resonance Imaging
Biological: Ipilimumab
Biological: Nivolumab
Radiation: Stereotactic Radiosurgery

First Posted Date: 2018-07-30

Last Posted Date: 2025-05-20

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 38

Registration Number: NCT03604978

Locations: 🇺🇸
Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States
🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States
🇺🇸
UC San Diego Moores Cancer Center, La Jolla, California, United States

and more 26 locations

Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Phase 2

Suspended

Conditions: Clinical Stage II Esophageal Adenocarcinoma AJCC v8
Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
Esophageal Adenocarcinoma
Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8
Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage III Esophageal Adenocarcinoma AJCC v8
Gastroesophageal Junction Adenocarcinoma

Interventions: Procedure: Biospecimen Collection
Drug: Carboplatin
Procedure: Computed Tomography
Biological: Ipilimumab
Drug: Paclitaxel
Biological: Nivolumab
Procedure: Positron Emission Tomography
Radiation: Radiation Therapy

First Posted Date: 2018-07-30

Last Posted Date: 2025-06-05

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 278

Registration Number: NCT03604991

Locations: 🇺🇸
AdventHealth Porter, Denver, Colorado, United States
🇺🇸
Saint Anthony Hospital, Lakewood, Colorado, United States
🇺🇸
AdventHealth Littleton, Littleton, Colorado, United States

and more 486 locations

Testing Whether the Combination of Two Immunotherapy Drugs Have Activity in Recurrent or Persistent Clear Cell Ovarian Cancer

Phase 2

Completed

Conditions: Malignant Ovarian Clear Cell Tumor
Recurrent Ovarian Carcinoma

Interventions: Drug: Epacadostat
Biological: Pembrolizumab

First Posted Date: 2018-07-27

Last Posted Date: 2024-07-26

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 14

Registration Number: NCT03602586

Locations: 🇺🇸
Columbus Oncology and Hematology Associates Inc, Columbus, Ohio, United States
🇺🇸
Riverside Methodist Hospital, Columbus, Ohio, United States
🇺🇸
Grant Medical Center, Columbus, Ohio, United States

and more 360 locations

T Cells Expressing a Novel Fully-Human Anti-BCMA CAR for Treating Multiple Myeloma

Phase 1

Active, not recruiting

Conditions: Myeloma-Multiple
Myeloma, Plasma-Cell

Interventions: Drug: Cyclophosphamide
Drug: Fludarabine
Biological: Anti-B Cell Maturation Antigen (BCMA) chimeric antigen receptors (CARs) T cells

First Posted Date: 2018-07-27

Last Posted Date: 2025-02-25

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 35

Registration Number: NCT03602612

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Radiation Therapy With or Without Olaparib in Treating Patients With Inflammatory Breast Cancer

Phase 2

Active, not recruiting

Conditions: Breast Inflammatory Carcinoma

Interventions: Procedure: Biospecimen Collection
Drug: Olaparib
Radiation: Radiation Therapy
Other: Survey Administration

First Posted Date: 2018-07-26

Last Posted Date: 2025-03-21

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 300

Registration Number: NCT03598257

Locations: 🇺🇸
Anchorage Associates in Radiation Medicine, Anchorage, Alaska, United States
🇺🇸
Alaska Oncology and Hematology LLC, Anchorage, Alaska, United States
🇺🇸
Anchorage Oncology Centre, Anchorage, Alaska, United States

and more 217 locations

Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors

Phase 1

Active, not recruiting

Conditions: Refractory Primary Central Nervous System Neoplasm
Recurrent Diffuse Intrinsic Pontine Glioma
Recurrent Malignant Glioma
Recurrent Medulloblastoma
Recurrent Primary Central Nervous System Neoplasm
Refractory Diffuse Intrinsic Pontine Glioma
Refractory Malignant Glioma
Refractory Medulloblastoma

Interventions: Procedure: Biospecimen Collection
Procedure: Magnetic Resonance Imaging
Drug: Savolitinib
Procedure: X-Ray Imaging

First Posted Date: 2018-07-26

Last Posted Date: 2025-04-20

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 41

Registration Number: NCT03598244

Locations: 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
Lucile Packard Children's Hospital Stanford University, Palo Alto, California, United States
🇺🇸
Children's Hospital Colorado, Aurora, Colorado, United States

and more 9 locations

Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda Interferon

Phase 2

Completed

Conditions: Liver Disease
Hepatitis D

Interventions: Drug: Peg-interferon lambda
Drug: Lonafarnib
Drug: Ritonavir

First Posted Date: 2018-07-26

Last Posted Date: 2021-12-14

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 26

Registration Number: NCT03600714

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer

Phase 2

Active, not recruiting

Conditions: Metastatic Lung Non-Small Cell Carcinoma
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Refractory Lung Non-Small Cell Carcinoma

Interventions: Drug: Atezolizumab
Procedure: Biopsy Procedure
Procedure: Biospecimen Collection
Drug: Cobimetinib
Procedure: Computed Tomography
Procedure: Magnetic Resonance Imaging

First Posted Date: 2018-07-26

Last Posted Date: 2025-04-17

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 48

Registration Number: NCT03600701

Locations: 🇺🇸
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States
🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States
🇺🇸
Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

and more 15 locations

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