The McLean Hospital Corporation

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

Pharmacologic Augmentation of TMS for Depression with D-serine

Phase 1

Not yet recruiting

Conditions: Depression

First Posted Date: 2025-03-14

Last Posted Date: 2025-03-14

Lead Sponsor: Mclean Hospital

Target Recruit Count: 60

Registration Number: NCT06876129

Stress Dynamics and Familial Risk for Depression in Female Adolescents

Not Applicable

Not yet recruiting

Conditions: Major Depressive Disorder

First Posted Date: 2025-02-10

Last Posted Date: 2025-05-06

Lead Sponsor: Mclean Hospital

Target Recruit Count: 148

Registration Number: NCT06816329

Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans

Phase 2

Not yet recruiting

Conditions: Depression - Major Depressive Disorder
Anxiety
Stress

Interventions: Drug: Nociceptin Receptor Antagonist (LY-2940094)
Device: DS8R Biphasic Constant Current Stimulator

First Posted Date: 2025-01-22

Last Posted Date: 2025-05-07

Lead Sponsor: Mclean Hospital

Target Recruit Count: 50

Registration Number: NCT06786637

Open Label Extension Study of NCT06221852

Not Applicable

Conditions: Bipolar I Disorder
Schizoaffective Disorder
Psychosis

Interventions: Other: Ketogenic diet

First Posted Date: 2024-08-16

Last Posted Date: 2025-04-17

Lead Sponsor: Mclean Hospital

Target Recruit Count: 50

Registration Number: NCT06558201

Locations: 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States

Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

Phase 2

Recruiting

Conditions: Endometriosis

Interventions: Drug: Placebo
Drug: Cannabidiol

First Posted Date: 2024-06-27

Last Posted Date: 2025-03-18

Lead Sponsor: Mclean Hospital

Target Recruit Count: 30

Registration Number: NCT06477406

Locations: 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Not Applicable

Recruiting

Conditions: Schizoaffective Disorder
Psychosis
Bipolar I Disorder

Interventions: Other: Ketogenic diet
Other: Dietary Guidelines for Americans

First Posted Date: 2024-01-24

Last Posted Date: 2024-08-16

Lead Sponsor: Mclean Hospital

Target Recruit Count: 50

Registration Number: NCT06221852

Locations: 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States

MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

Phase 2

Recruiting

Conditions: Schizophrenia and Related Disorders
Cognitive Impairment
Mitochondrial Alteration

Interventions: Drug: Placebo
Drug: MitoQ

First Posted Date: 2024-01-05

Last Posted Date: 2025-05-20

Lead Sponsor: Mclean Hospital

Target Recruit Count: 100

Registration Number: NCT06191965

Locations: 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States
🇨🇭
University of Lausanne, Lausanne, Switzerland
🇺🇸
Yale School of Medicine, New Haven, Connecticut, United States

Mechanisms of Exposure Therapy for OCD

Not Applicable

Recruiting

Conditions: Obsessive-Compulsive Disorder

Interventions: Behavioral: Exposure therapy

First Posted Date: 2023-12-18

Last Posted Date: 2024-11-01

Lead Sponsor: Mclean Hospital

Target Recruit Count: 400

Registration Number: NCT06173752

Locations: 🇺🇸
Center for Understanding and Treating Anxiety, San Diego, California, United States
🇺🇸
McLean OCDI, Belmont, Massachusetts, United States

Online Emotional Response to Completing a Childhood Maltreatment Self-report Scale

Completed

Conditions: Stress, Psychological
Stress, Emotional

Interventions: Behavioral: Maltreatment and Abuse Chronology of Exposure Scale as a stress challenge
Behavioral: Standardized Maths and Verbal Questions such as the ones used in SATs
Behavioral: Chronology of Perceived Discrimination Scale (CPDS)
Behavioral: International Personality Item Pool (IPIP-NEO)

First Posted Date: 2023-11-30

Last Posted Date: 2024-03-13

Lead Sponsor: Mclean Hospital

Target Recruit Count: 500

Registration Number: NCT06152549

Locations: 🇺🇸
McLean Hospital through ProlificTM, Belmont, Massachusetts, United States

Cerebellar Modulation of Cognition in Psychosis

Not Applicable

Recruiting

Conditions: Schizoaffective Disorder
Bipolar Disorder I
Psychosis
Schizophrenia

Interventions: Device: continuous theta burst stimulation (cTBS)
Device: intermittant theta burst stimulation (iTBS)
Device: sham rTMS

First Posted Date: 2023-10-30

Last Posted Date: 2024-08-07

Lead Sponsor: Mclean Hospital

Target Recruit Count: 95

Registration Number: NCT06107764

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸
McLean Hospital, Belmont, Massachusetts, United States

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