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BRISTOL MYERS SQUIBB

🇺🇸United States
Ownership
-
Established
1989-01-01
Employees
30K
Market Cap
$97.5B
Website
https://www.bms.com/

A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)

Phase 3
Not yet recruiting
Conditions
Alzheimer Disease
Psychosis
Interventions
Drug: KarXT + KarX-EC Arm Matching Placebo
First Posted Date
2025-04-27
Last Posted Date
2025-04-27
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
1046
Registration Number
NCT06947941

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

Phase 2
Not yet recruiting
Conditions
Non-Small Cell Lung Cancer
Interventions
First Posted Date
2025-04-27
Last Posted Date
2025-05-11
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
76
Registration Number
NCT06946797
Locations
🇵🇱

Local Institution - 0079, Łódź, Łódzkie, Poland

🇧🇷

Local Institution - 0041, Brasilia, Distrito Federal, Brazil

🇺🇸

Local Institution - 0032, Anchorage, Alaska, United States

and more 45 locations

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

Phase 3
Not yet recruiting
Conditions
Alzheimer Disease
Agitation
Interventions
First Posted Date
2025-04-22
Last Posted Date
2025-05-28
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
600
Registration Number
NCT06937229
Locations
🇺🇸

Local Institution - 2609, Chandler, Arizona, United States

🇺🇸

Local Institution - 1619, Scottsdale, Arizona, United States

🇺🇸

Local Institution - 2620, Canoga Park, California, United States

and more 149 locations

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Phase 1
Recruiting
Conditions
Mesothelioma
Non Small Cell Lung Cancer
Malignant Peripheral Nerve Sheath Tumors
Solid Tumor
Pancreatic Adenocarcinoma
Advanced Solid Tumor
Interventions
First Posted Date
2025-04-22
Last Posted Date
2025-04-22
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
320
Registration Number
NCT06937970
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Rocky Mountain Cancer Centers, LLP - Oncology, Lone Tree, Colorado, United States

🇺🇸

Sarah Cannon Research Institute (SCRI) - HealthONE Location, Denver, Colorado, United States

and more 19 locations

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Phase 3
Not yet recruiting
Conditions
Bipolar Disorder Type I With Mania
Interventions
First Posted Date
2025-04-16
Last Posted Date
2025-05-28
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
300
Registration Number
NCT06929273
Locations
🇺🇸

Local Institution - 0123, Torrance, California, United States

🇺🇸

Local Institution - 0026, Hialeah Gardens, Florida, United States

🇺🇸

Local Institution - 0059, Hollywood, Florida, United States

and more 119 locations

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

Phase 2
Not yet recruiting
Conditions
Breast Neoplasms
Interventions
First Posted Date
2025-04-15
Last Posted Date
2025-05-18
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
560
Registration Number
NCT06926868
Locations
🇺🇸

Local Institution - 0303, Hot Springs, Arkansas, United States

🇺🇸

Local Institution - 0307, Cerritos, California, United States

🇺🇸

Local Institution - 0308, Cerritos, California, United States

and more 217 locations

A Study to Investigate the Safety, Tolerability, and Drug Levels of BMS-986419 (Part 1) and the Effects Multiple Doses of BMS-986419 on Cardiac Repolarization (Part 2) in Healthy Participants

Phase 1
Recruiting
Conditions
Healthy Volunteers
Interventions
Drug: BMS-986419 Matching Placebo
Drug: Moxifloxacin Matching Placebo
First Posted Date
2025-03-25
Last Posted Date
2025-04-01
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
74
Registration Number
NCT06846866
Locations
🇺🇸

Celerion, Tempe, Arizona, United States

A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia

Phase 3
Not yet recruiting
Conditions
Schizophrenia
Interventions
Other: Placebo
First Posted Date
2025-03-19
Last Posted Date
2025-05-28
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
250
Registration Number
NCT06882785
Locations
🇯🇵

Local Institution - 0034, Konan, Aichi, Japan

🇯🇵

Local Institution - 0001, Toyoake, Aichi, Japan

🇯🇵

Local Institution - 0003, Toyoake, Aichi, Japan

and more 44 locations

A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132

Phase 4
Not yet recruiting
Conditions
Systemic Lupus Erythematosus (SLE)
Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE)
Interventions
First Posted Date
2025-03-14
Last Posted Date
2025-03-14
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
35
Registration Number
NCT06875960
Locations
🇺🇸

Local Institution - 0001, Farmington, Connecticut, United States

🇺🇸

Local Institution - 0002, New York, New York, United States

🇺🇸

Local Institution - 0003, Jackson, Tennessee, United States

A Single-dose Study to Evaluate the Safety, Tolerability, Drug Levels, and Relative Biological Availability of Alternate Formulations of BMS-986460 in Healthy Adult Male Participants

Phase 1
Recruiting
Conditions
Healthy Volunteers
Interventions
First Posted Date
2025-03-14
Last Posted Date
2025-05-15
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
56
Registration Number
NCT06877702
Locations
🇺🇸

ICON Lenexa, Lenexa, Kansas, United States

🇺🇸

Local Institution - 0002, Lenexa, Kansas, United States

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