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BRISTOL MYERS SQUIBB

🇺🇸United States
Ownership
-
Established
1989-01-01
Employees
30K
Market Cap
$97.5B
Website
https://www.bms.com/

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

Phase 3
Not yet recruiting
Conditions
Alzheimer's Disease
Interventions
First Posted Date
2025-05-16
Last Posted Date
2025-06-17
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
586
Registration Number
NCT06976203
Locations
🇺🇸

Local Institution - 0072, Fullerton, California, United States

🇺🇸

Local Institution - 0091, Inglewood, California, United States

🇺🇸

Local Institution - 0095, Irvine, California, United States

and more 112 locations

A Study to Evaluate Treatment Patterns and Effectiveness of Luspatercept

Active, not recruiting
Conditions
Myelodysplastic Syndromes (MDS)
Interventions
Drug: Erythropoiesis-stimulating agent (ESA)
First Posted Date
2025-05-14
Last Posted Date
2025-05-14
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
430
Registration Number
NCT06971185
Locations
🇺🇸

Bristol Myers Squibb, Princeton, New Jersey, United States

A Study to Assess Drug Levels, Tolerability and Absolute Biological Availability of Single-dose of BMS-986446 in Healthy Participants

Phase 1
Recruiting
Conditions
Healthy Volunteer
Interventions
Drug: BMS-986446 IV
Drug: BMS-986446 SC
First Posted Date
2025-05-02
Last Posted Date
2025-05-21
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
46
Registration Number
NCT06955741
Locations
🇺🇸

Anaheim Clinical Trials LLC (ACT), Anaheim, California, United States

🇺🇸

Local Institution - 10000, Anaheim, California, United States

🇺🇸

Local Institution - 9999, Anaheim, California, United States

A Study Comparing the Risk of Serious Infections and Malignancies With Deucravacitinib or Biologics in Japanese Patients With Psoriasis

Active, not recruiting
Conditions
Psoriasis
Interventions
Biological: Any biologic treatment for psoriasis
First Posted Date
2025-05-01
Last Posted Date
2025-05-01
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
2000
Registration Number
NCT06952465
Locations
🇯🇵

Local Institution, Tokyo, Japan

🇯🇵

Medical Data Vision, Inc, Tokyo, Japan

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

Phase 3
Recruiting
Conditions
Bipolar-I Disorder With Mania or Mania With Mixed Features
Interventions
Other: Placebo
First Posted Date
2025-04-30
Last Posted Date
2025-06-19
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
274
Registration Number
NCT06951698
Locations
🇺🇸

Local Institution - 0058, Bentonville, Arkansas, United States

🇺🇸

Local Institution - 0011, Little Rock, Arkansas, United States

🇺🇸

Local Institution - 0005, Anaheim, California, United States

and more 58 locations

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

Phase 3
Recruiting
Conditions
Bipolar Disorder Type I With Mania or Mania With Mixed Features
Interventions
Other: Placebo
First Posted Date
2025-04-30
Last Posted Date
2025-06-29
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
274
Registration Number
NCT06951711
Locations
🇺🇸

Local Institution - 0014, Little Rock, Arkansas, United States

🇺🇸

Local Institution - 0025, Rogers, Arkansas, United States

🇺🇸

Local Institution - 0021, Culver City, California, United States

and more 62 locations

A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)

Phase 3
Not yet recruiting
Conditions
Alzheimer Disease
Psychosis
Interventions
Drug: KarXT + KarX-EC Arm Matching Placebo
First Posted Date
2025-04-27
Last Posted Date
2025-04-27
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
1046
Registration Number
NCT06947941

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

Phase 2
Recruiting
Conditions
Non-Small Cell Lung Cancer
Interventions
First Posted Date
2025-04-27
Last Posted Date
2025-06-29
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
76
Registration Number
NCT06946797
Locations
🇺🇸

Alaska Oncology and Hematology, Anchorage, Alaska, United States

🇺🇸

Local Institution - 0062, Los Angeles, California, United States

🇺🇸

Local Institution - 0063, Boise, Idaho, United States

and more 45 locations

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

Phase 3
Not yet recruiting
Conditions
Alzheimer Disease
Agitation
Interventions
First Posted Date
2025-04-22
Last Posted Date
2025-06-25
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
600
Registration Number
NCT06937229
Locations
🇺🇸

Local Institution - 2609, Chandler, Arizona, United States

🇺🇸

Local Institution - 1619, Scottsdale, Arizona, United States

🇺🇸

Local Institution - 2620, Canoga Park, California, United States

and more 171 locations

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Phase 1
Recruiting
Conditions
Mesothelioma
Non Small Cell Lung Cancer
Malignant Peripheral Nerve Sheath Tumors
Solid Tumor
Pancreatic Adenocarcinoma
Advanced Solid Tumor
Interventions
First Posted Date
2025-04-22
Last Posted Date
2025-04-22
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
320
Registration Number
NCT06937970
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Sarah Cannon Research Institute (SCRI) - HealthONE Location, Denver, Colorado, United States

🇺🇸

Rocky Mountain Cancer Centers, LLP - Oncology, Lone Tree, Colorado, United States

and more 19 locations
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