Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia
Phase 3
Not yet recruiting
- Conditions
- Acute Myeloid LeukemiaRecurrent Acute Myeloid Leukemia
- Interventions
- Other: Best PracticeProcedure: Biospecimen CollectionOther: Electronic Health Record ReviewOther: Xylitol-containing Oral WipeDrug: Placebo Administration
- First Posted Date
- 2025-06-15
- Last Posted Date
- 2025-06-15
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 556
- Registration Number
- NCT07022678
Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma
Phase 1
Recruiting
- Conditions
- Childhood AstrocytomaChildhood Diffuse Intrinsic Pontine GliomaChildhood Diffuse Midline GliomaChildhood GlioblastomaChildhood Malignant Glioma
- Interventions
- Drug: ATM Kinase Inhibitor AZD1390Procedure: Biospecimen CollectionProcedure: Magnetic Resonance ImagingRadiation: Radiation TherapyOther: Survey Administration
- First Posted Date
- 2025-03-26
- Last Posted Date
- 2025-06-10
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 54
- Registration Number
- NCT06894979
- Locations
- 🇺🇸
Saint Jude Children's Research Hospital, Memphis, Tennessee, United States
Comparing 123I-MIBG and 18F-MFBG Imaging in Patients With Newly Diagnosed, High Risk Neuroblastoma
Phase 2
Not yet recruiting
- Conditions
- GanglioneuroblastomaGanglioneuroblastoma, NodularHigh Risk Neuroblastoma
- First Posted Date
- 2025-03-05
- Last Posted Date
- 2025-06-25
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 84
- Registration Number
- NCT06858501
Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body
Phase 2
Not yet recruiting
- Conditions
- CIC-Rearranged SarcomaSarcoma With BCOR Genetic AlterationsMetastatic Ewing SarcomaMetastatic High Grade SarcomaMetastatic Undifferentiated Round Cell SarcomaRound Cell Sarcoma With EWSR1-non-ETS FusionMetastatic Undifferentiated Sarcoma, Not Otherwise Specified
- Interventions
- Procedure: Biopsy ProcedureProcedure: Biospecimen CollectionProcedure: Bone Marrow AspirationProcedure: Bone Marrow BiopsyProcedure: Computed TomographyProcedure: Echocardiography TestOther: Fludeoxyglucose F-18Procedure: Magnetic Resonance ImagingProcedure: Positron Emission TomographyOther: Questionnaire AdministrationRadiation: Radiation TherapyProcedure: Surgical Procedure
- First Posted Date
- 2025-02-11
- Last Posted Date
- 2025-04-10
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 437
- Registration Number
- NCT06820957
Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma
Phase 3
Recruiting
- Conditions
- Pleuropulmonary Blastoma
- Interventions
- Procedure: Biospecimen CollectionProcedure: Computed TomographyProcedure: Bone ScanOther: Patient ObservationProcedure: Ultrasound ImagingProcedure: Echocardiography TestProcedure: Magnetic Resonance ImagingProcedure: Multigated Acquisition ScanProcedure: Positron Emission Tomography
- First Posted Date
- 2024-10-18
- Last Posted Date
- 2025-06-10
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 110
- Registration Number
- NCT06647953
- Locations
- 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸Arnold Palmer Hospital for Children, Orlando, Florida, United States
🇺🇸Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, United States
A Study of Different Programs to Help ALL Patients With Taking Maintenance Medicine at Home
Not Applicable
Recruiting
- Conditions
- Acute Lymphoblastic LeukemiaChildhood Acute Lymphoblastic Leukemia
- Interventions
- Procedure: Biospecimen CollectionOther: Informational InterventionBehavioral: Compliance MonitoringOther: Media InterventionOther: Health Promotion and EducationOther: Medical Device Usage and EvaluationOther: Questionnaire AdministrationBehavioral: Training and EducationBehavioral: Telephone-Based Intervention
- First Posted Date
- 2024-10-15
- Last Posted Date
- 2025-02-12
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 64
- Registration Number
- NCT06639958
- Locations
- 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸Arkansas Children's Hospital, Little Rock, Arkansas, United States
🇺🇸Kaiser Permanente-Oakland, Oakland, California, United States
Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma
Phase 1
Recruiting
- Conditions
- Childhood Fibrolamellar CarcinomaRecurrent Childhood Fibrolamellar CarcinomaRecurrent Childhood Malignant Solid NeoplasmRecurrent Fibrolamellar CarcinomaRecurrent Malignant Solid NeoplasmRefractory Childhood Fibrolamellar CarcinomaRefractory Childhood Malignant Solid NeoplasmRefractory Fibrolamellar CarcinomaRefractory Malignant Solid Neoplasm
- Interventions
- Biological: Bcl-XL Proteolysis Targeting Chimera DT2216Procedure: Biospecimen Collection
- First Posted Date
- 2024-10-01
- Last Posted Date
- 2025-06-11
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 81
- Registration Number
- NCT06620302
- Locations
- 🇺🇸
Saint Jude Children's Research Hospital, Memphis, Tennessee, United States
🇺🇸Riley Hospital for Children, Indianapolis, Indiana, United States
🇺🇸Memorial Sloan Kettering Cancer Center, New York, New York, United States
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Phase 3
Recruiting
- Conditions
- Malignant Solid NeoplasmHematopoietic and Lymphatic System Neoplasm
- Interventions
- Other: Best PracticeOther: Electronic Health Record ReviewProcedure: Biospecimen CollectionOther: Survey Administration
- First Posted Date
- 2024-07-22
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 60
- Registration Number
- NCT06513962
- Locations
- 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States
🇺🇸Arkansas Children's Hospital, Little Rock, Arkansas, United States
A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study
Phase 2
Active, not recruiting
- Conditions
- Malignant Solid NeoplasmHematopoietic and Lymphatic System Neoplasm
- Interventions
- Other: Goal SettingOther: InterviewOther: Media InterventionOther: Medical Device Usage and EvaluationOther: Questionnaire AdministrationOther: RewardOther: Text Message-Based Navigation Intervention
- First Posted Date
- 2024-05-13
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 190
- Registration Number
- NCT06410209
- Locations
- 🇺🇸
Banner Children's at Desert, Mesa, Arizona, United States
🇺🇸Kaiser Permanente Downey Medical Center, Downey, California, United States
🇺🇸City of Hope Comprehensive Cancer Center, Duarte, California, United States
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
Phase 3
Recruiting
- Conditions
- Stage I Kidney Wilms TumorStage II Kidney Wilms TumorStage III Kidney Wilms TumorStage IV Kidney Wilms Tumor
- Interventions
- Procedure: Computed TomographyProcedure: NephrectomyProcedure: Bone ScanOther: Patient ObservationProcedure: Magnetic Resonance ImagingProcedure: Positron Emission TomographyProcedure: Ultrasound ImagingProcedure: X-Ray Imaging
- First Posted Date
- 2024-05-06
- Last Posted Date
- 2025-06-10
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 1656
- Registration Number
- NCT06401330
- Locations
- 🇺🇸
Providence Alaska Medical Center, Anchorage, Alaska, United States
🇺🇸Banner Children's at Desert, Mesa, Arizona, United States
🇺🇸Arkansas Children's Hospital, Little Rock, Arkansas, United States